Heat‐Shock Protein 60: Implications for Pathogenesis of and Protection against Bacterial Infections
1991; Wiley; Volume: 121; Issue: 1 Linguagem: Inglês
10.1111/j.1600-065x.1991.tb00823.x
ISSN1600-065X
AutoresStefan H. E. Kaufmann, Bernd Schoel, Jan D. A. van Embden, Tetsuja Koga, A. Wand-Württenberger, Martin E. Munk, Ulrich Steinhoff,
Tópico(s)Viral gastroenteritis research and epidemiology
ResumoImmunological ReviewsVolume 121, Issue 1 p. 67-90 Heat-Shock Protein 60: Implications for Pathogenesis of and Protection against Bacterial Infections Stefan H. E. Kaufmann, Corresponding Author Stefan H. E. Kaufmann Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmProf. Dr. S. H. E. Kaufmann, Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 Ulm, FRG. Tel.: 0731/176-3387; Telefax: 073i/176-3372.Search for more papers by this authorBernd Schoel, Bernd Schoel Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorJ. D. A. V. Embden, J. D. A. V. Embden National Institute for Public Health and Environmental Hygiene, Bilthoven, The Netherlands.Search for more papers by this authorTetsuja Koga, Tetsuja Koga Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorAngela Wand-Württenberger, Angela Wand-Württenberger Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorMartin E. Munk, Martin E. Munk Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorUlrich Steinhoff, Ulrich Steinhoff Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this author Stefan H. E. Kaufmann, Corresponding Author Stefan H. E. Kaufmann Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmProf. Dr. S. H. E. Kaufmann, Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 Ulm, FRG. Tel.: 0731/176-3387; Telefax: 073i/176-3372.Search for more papers by this authorBernd Schoel, Bernd Schoel Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorJ. D. A. V. Embden, J. D. A. V. Embden National Institute for Public Health and Environmental Hygiene, Bilthoven, The Netherlands.Search for more papers by this authorTetsuja Koga, Tetsuja Koga Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorAngela Wand-Württenberger, Angela Wand-Württenberger Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorMartin E. Munk, Martin E. Munk Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this authorUlrich Steinhoff, Ulrich Steinhoff Department of Immunology, University of Ulm, Albert-Einstein-Allee 11, D-7900 UlmSearch for more papers by this author First published: June 1991 https://doi.org/10.1111/j.1600-065X.1991.tb00823.xCitations: 82AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL REFERENCES Ab, B. K., Kiessling, R., van Embden, J. D. A., Thole, J. E. R., Kumararatne, D. S., Pisa, P., Wondimu, A. & Ottenhoff, T. H. M. (1990) Induction of antigen-specific CD4+ HLA-DR-restricted cytotoxic T lymphocytes as well as nonspecific nonrestricted killer cells by the recombinant mycobacterial 65-kDa heat shock protein. Eur. J. Immunol. 20, 369. Ananthan, J., Goldberg, A. L. & Voellmy, R. (1986) Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes. Science 232, 322. Anderson, D. C., Barry, M. E. & Buchanan, T. M. (1988) Exact definition of species-specific and cross-reactive epitopes of the 65 kilodalton protein of Myeobacterium leprae using synthetic peptides. J. Immunol. 141, 607. Antia, N. H. (1982) Leprosy a disease of the Schwann cell. Lepr India 54, 599. Asarnow, D. M., Kuziel, W. A., Bonyhadi, M., Tigelaar, R. E., Tucker, P. W. & Allison, J. P. (1988) Limited diversity of γ/δ antigen receptor genes of Thy-1 + dendritic epidermal cells. Cell 55, 837. Asherson, G. L. (1968) The role of microorganisms in autoimmune responses. Progr. Allergy 12, 192. Atkinson, M. A., Maclaren, N. K. & Scharp, D. W. (1990) Letter to the editor. Lancet 336, 1251. Baekeskov, S., Jan-Aanstoot, H. & Christgau, S. (1990) Identification of the 65K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase. Nature 347, 151. Blachard, D. K., Stewart II, W. E., Klein, T. W., Friedmann, H. & Djeu, J. Y. (1987) Cytolytic activity of human peripheral blood leukocytes against Legionella pneumophila-infected monocytes; characterization of the effector cell and augmentation by interleukin 2. J. Immunol. 139, 551. Born, W., Hall, L., Dallas, A., Boymel, J., Shinnick, T., Young, D., Brennan, P. & O'Brien, R. (1990b) Recognition of a peptide antigen by heat shock reactive γ/δ T lymphocytes. Science 249, 67. Bom, W., Happ, M. P., Dallas, A., Reardon, C., Kubo, R., Shinnick, T., Brennan, P. & O'Brien, R. (1990a) Recognition of heat shock proteins and γ/δ T cell function. Immunol. Today 11, 40. Buchanan, T. M., Nomaguchi, H., Anderson, D. C., Young, R. A., Gillis, T. P., Britton, W. J., Ivanyi, J., Kolk, A. H. J., Doss, O., Bloom, B. R. & Mehra, V. (1987) Characterization of antibody-reactive epitopes on the 65 kilodalton protein of Mycobacterium leprae. Infect. Immun. 55, 1000. Buchmeier, N. A. & Heffron, F. (1990) Salmonella proteins induced following phagocytosis by macrophages are controlled by multiple regulons. Science 248, 730. Carbone, F. R., Moore, M. W., Sheil, J. M. & Bevan, M. J. (1988) Induction of cytotoxic T lymphocytes by primary in vitro stimulation with peptides. J. Exp. Med. 167, 1767. Carl, M. & Dasch, G. A. (1986) Characterization of human cytotoxic lymphocytes directed against cells infected with typhus group rickettsiae: evidence for lymphokine activation of effectors. J. Immunol. 136, 2654. De Bruyn, J., Bosmans, R., Tumeer, M., Weckx, M., Myabenda, J., van Vooren, J. P., Falmagne, P., Wiker, H. G. & Harboe, M. (1987) Purification, partial characterization, and identification of a skin reactive protein antigen of Mycobacterium bovis BCG. Infect. Immun. 55, 245. Dudani, A. K. & Gupta, R. S. (1989) Immunological characterization of a homolog of the 65-kiIodalton mycobacterial antigen. Infect. Immun. 57, 2786. Elias, D., Markovits, D., Reshef, T., van der Zee, R. & Cohen, I. R. (1990) Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65- kDa heat shock protein. Proc. Natl. Acad. Sci. USA 87, 1576. Emmrich, F., Thole, J., van Embden, J. & Kaufmann, S. H. E. (1986) A recombinant 64 kilo Dalton protein of Mycobacterium bovis BCG specifically stimulates human T4 clones reactive to mycobacterial antigens. J. Exp. Med. 163, 1024. Engers, H. D., Houba, V., Bennedsen, J., Buchanan, T. M., Chaparas, S. D., Kadival, G., Closs, O., David, J. R., van Embden, J. D. A., Godal, T., Mustafa, S. A., Ivanyi, J., Young, D. B., Kaufmann, S. H. E., Khomenko, A. G., Kolk, A. H. J., Kubin, M., Louis, J. A., Minden, P., Shinnick, T. M., Trnka, L. & Young, R. A. (1986) Letter to the Editor: Results of a World Health Organization-sponsored workshop to characterize antigens recognized by Mycobacterium-specific monoclonal antibodies. Infect. Immun. 51, 718. Fisch, P., Malkovsky, M., Kovats, S., Stunn, E., Braakman, E., Klein, B. S., Voss, D., Morrissey, L. W., DeMars, R., Welch, W. J., Bolhuis, R. L. H. & Sondel, P. M. (1990) Recognition of human Vγ9/Vδ52 T-cells of a GroEL homolog on Daudi Burkitt's lymphoma cells. Science 250, 1269. Flesch, I. & Kaufmann, S. H. E. (1987) Mycobacterial growth inhibition by interferon- activated bone marrow macrophages and differential susceptibility among strains of Mycobaeterium tuberculosis. J. Immunol. 138, 4408. Flynn, G. C., Chappell, T. G. & Rothman, J. E. (1989) Peptide binding and release by proteins implicated as catalysts of protein assembly. Science 245, 385. Gaston, J. S. H., Lofe, P., Jenner, P. J., Colston, M. J. & Bacon, P. A. (1990) Recognition of a mycobaeteria-specific epitope in the 65 kilodalton heal-shoek protein by synovial fluid-derived T-cell clones. J. Exp. Med. 771, 831. Gromkowski, S. H., Yagi, J. & Janeway, C. A. Jr. (1989) Elevated temperature regulates tumor necrosis factor-mediated immune killing. Eur. J, Immunol. 19, 1709. Gupta, R. S. (1990) Sequenee and structural homology between a mouse T-complex protein TCP-1 and the "chaperonin" family of bacterial (GroEL, 60-65 kDa heat shock antigen) and eukaryotie proteins. Biochem. Intern. 20, 833. Haregewoin, A., Soman, G., Hom, C. R. & Finberg, R. W. (1989) Human γδ+ T cells respond to mycobaeterial heat-shock protein. Nature 340, 309. Hendrix, R. W. (1979) Purification and properties of GroEL a host protein in bacteriophage assembly. Mol. Biol. 129, 375. Hoiseth, S. K. & Stocker, B. A. D. (1981) Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291, 238. Holoshitz, J., Koning, F., Coligan, J. E., De Bruyn, J. & Strober, S. (1989) Isolation of CD4- CD8- mycobacteria-reactive T lymphocyte clones from rheumatoid arthritis synovial fluid. Nature 339, 226. Ivanyi, J., Sinha, S., Aston, R., Cussell, D., Keen, M. & Sengupta, U. (1983) Definition of species specific and cross-reactive antigenic determinants of Mycobacterium leprae using monoclonal antibodies. Clin. Exp. Immunol. 52, 528. Jarjour, W., Mizzen, L. A., Welch, W. J., Denning, S., Shaw, M., Mimura, T., Haynes, B. F. & Winfield, J. B. (1990) Constitutive expression of a groEL-related protein on the surface of human cells. J. Exp. Med. 172, 1857. Jindal, S., Dudani, A. K., Singh, B., Harley, C. B. & Gupta, R. S. (1989) Primary structure of a human mitochondnal protein homologous to the bacterial and plant chaperonins and to the 65-kiloDafton mycobacterial antigen. Mol. Cell. Biol. 9, 2279. Jones, D. B., Hunter, N. R. & Duff, G. W. (1990) Heat-shock protein 65 as β cell antigen of insulin-dependent diabetes. Lancet 336, 583. Kabelitz, D., Bender, A., Schondelmaier, S., Schoel, B. & Kaufmann, S. H. E. (1990) A large fraction of human peripheral blood γδ+ T cells is activated by Mycobacterium tuberculosis but not by its 65 kD heat shock protein. J. Exp. Med. 171, 667. Kämpe, O., Velloso, L., Andersson, A. & Karlsson, A. (1990) Letter to the editor. Lancer 336, 1250. Kantengwa, S., Donati, Y. R. A., Clerget, M., Maridonneau-Parini, I., Sinclair, F., Mariéthoz, E., Rees, A. D. M., Slosman, D. O. & Polla, B. S. (1991) Heat shock proteins: an autoprotective mechanism for inflammatory cells Sem. Immunol, (in press). Kaplan, G., Kiessling, R., Teklemariam, S., Hancock, G., Sheftel, G., Job, C. K., Converse, P., Ottenhoff, T. H. M., Becx-Bleumink, M., Dietz, M. & Cohn, Z. A. (1989) The reconstitution of cell-mediated immunity in the cutaneous lesions of lepromatous leprosy by recombinant interleukin 2. J. Exp. Med. 169, 893. Kaufmann, S. H. E. (1986) Immunology of leprosy: new facts, future perspectives. Microbial Pathogen. 1, 107. Kaufmann, S. H. E. (1987) Towards new leprosy and tuberculosis vaccines. Micobiol. Sciences 4, 324. Kaufmann, S. H. E. (1988) CD8+ T lymphocytes in intracellular microbial infections. Immunol Today 9, 168. Kaufmann, S. H. E. (1990) Heat shock proteins: a link between rheumatoid arthritis and infection Curr. Opin. Rheumatol 2, 430. Kaufmann, S. H. E. & Kabelitz, D. (1991) Gamma/delta T lymphocytes and heat shock proteins. Curr. Top. Microbiol. Immunol. 167, 191. Kaufmann, S. H. E., Sehoel, B., Wand-Württenberger, A., Steinhoff, U., Munk, M. E. & Koga, T. (1990) T cells, stress proteins and pathogenesis of mycobaeterial infections. Curr. Top. Microbiol. Immunol. 155, 125. Kaufmann, S. H. E., Väth, U., Thole, J. E. R., Embden, J. D. A. & Emmrieh, F. (1987) Enumeration of T eells reactive with Mycobacterium tuberculosis organisms and specific for the recombinant mycobacterial 64 kiloDalton protein. Eur. J. Immunol. 11, 351. Klimpel, G. R., Niesel, D. W. & Klimpel, K. D. (1986) Natural cytotoxic effector cell activity against Shigella flexneri-infected HeLa cells. J. Immunol. 136, 1081. Koga, T., Wand-Württenberger, A., DeBruyn, J., Munk, M. E., Schoel, B. & Kaufmann, S. H. E. (1989) T cells against a bacterial heat shock protein recognize stressed macrophages. Science 245, 1112. Lamb, J. R., Bal, V., Mendez-Samperio, P., Mehlert, A., So, A., Rothbard, J., Jindal, S., Young, R. A. & Young, D. B. (1989) Stress proteins may provide a link between the immune response to infection and autoimmunity. Int. Immunol. 1, 191. Langer, T. & Neupert, W. (1991) Heat shock proteins hsp 60 and hsp 70: their roles in folding, assembly and membrane translocation of proteins. Curr. Top. Microbiol. Immunol. 167, 3. Mehra, V., Sweetser, D. & Young, R. A. (1986) Efficient mapping of protein antigenic determinants. Proc. Natl. Acad. Sci. USA 83, 7013. Mor, N. (1983) Intracellular location of Mycobacterium leprae in macrophages of normal and immune-deficient mice and effect of rifampin. Infect. Immun. 42, 802. Morrison, R. P., Belland, R. J., Lying, K. & Caldwell, H. D. (1989) Chlamydial disease pathogenesis. The 57-kD chlamydial hypersensitivity antigen is a stress response protein. J. Exp. Med 170, 1271. Mueller, D. L., Jenkins, M. K. & Schwartz, R. H. (1989) Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 7, 445. Muller, I. & Kaufmann, S. H. E. (1985) Antigen-reactivity pattern of T cell hybridomas from Mycobacterium bovis BCG-infected mice. Infect, Immun. 49, 838. Müller, I., Mayer, B., Brinkmann, V. & Kaufmann, S. H. E. (1986a) Autoreactive T-cell clones from mice infected with Mycobacterium bovis, strain bacillus Calmette-Guérin (BCG): I. Phenotype, specificity and in-vitro function. Immunobiology 171, 366. Müller, I., Rolink, A., Freudenberg, N. & Kaufmann, S. H. E. (1986b) Biological functions in vitro and in vivo of cloned autoreactive T cells. In: Leukocytes in Host Defense, J. J. Oppenheim & D. M. Jacobs, eds Alan R. Liss, Inc., New York , pp. 325– 330. Munk, M. E., Sehoel, B. & Kaufmann, S. H. E. (1988) T cell responses of normal individuals towards recombinant protein antigens of Mycobacterium tuberculosis. Eur. J. Immunol. 18, 1835. Munk, M. E., Schoel, B., Modrow, S., Karr, R. W., Young, R. A. & Kaufmann, S. H. E. (1989) Cytolytic T lymphocytes from healthy individuals with specificity to self epitopes shared by the mycobacterial and human 65 kDa heat shock protein. J. Immunol. 143, 2844. Munk, M. E., Shinnick, T. M. & Kaufmann, S. H. E. (1990) Epitopes of the Mycobacterium tuberculosis 65 kDa heat shock protein for human T cells comprise different secondary protein structures. Immunobiology 180, 272. Pierce, S. K., De Nagel, D. C. & van Buskirk, A. M. (1991) A role for heat shock proteins in antigen processing and presentation. Curr Top. Microbiol. Immunol. 167, 83. Rajagopalan, S., Zordan, T., Tsokos, G. C. & Datta, S. K. (1990) Pathogenic anti-DNA autoantibody-inducing T helper cell lines from patients with active lupus nephritis: Isolation of CD4−CD8− T helper cell lines that express the γ/δ T-cell antigen receptor Proc. Natl Acad. Sci. USA 87, 7020. Renkonen, R., Ristimäki, A. & Hayry, P. (1988) Interferon-gamma protects human endothelial cells from lymphokine-activated killer cell-mediated lysis. Eur. J Immunol 18, 1839. Shinnick, T. M. (1991) Heat shock proteins as antigens of bacterial and parasitic pathogens. Curr. Top, Microbiol. Immunol. 167, 145. Shoenfeld, Y. & Isenberg, D. A. (1988) Mycobacteria and autoimmunity. Immunol. Today 9, 178. Srivastava, P. K. & Maki, R. G. (1991) Stress-induced proteins in immune response to cancer. Curr. Top. Microbiol. Immunol. 167, 109. Steinhoff, U. & Kaufmann, S. H. E. (1988) Specific lysis by CD8+ T cells of Schwann cells expressing Mycobacterium leprae antigens, Eur. J. Immunol. 18, 973. Steinhoff, U., Schoel, B. & Kaufmann, S. H. E. (1990) Lysis of interferon-y activated Schwann cells by crossreactive CD8 a/β T cells with specificity to the mycobacterial 65 kDa heat shock protein. International Immunol. 2, 279. Steinhoff, U., Wand-Württenberger, A., Bremerich, A. & Kaufmann, S. H. E. (1991) Mycobacterium leprae renders Schwann cells and mononuclear phagocytes susceptible or resistant against killer cells. Infect. Immun. 59, 684. Sugawara, S., Nowicki, M., Xie, S., Song, H. J. & Dennert, G. (1990) Effects of stress on lysability of tumor targets by cytotoxic T cells and tumor necrosis factor. J. Immunol 145, 1991. Thole, J. E. R., Keulen, W. J., Kolk, A. H. J., Groothuis, D. G., Berwald, L. C., Tiesjema, R. H. & van Embden, J. D. A. (1987) Characterization, sequence determination, and immunogenicity of a 64-kilodalton protein of Mycobacterium bovis BCG expressed in Escherichia coli K-12. Infect. Immun. 55, 146. Townsend, A. & Bodmer, H. (1989) Antigen recognition by class I-restricted T lymphocytes. Ann. Rev. Immunol. 7, 601. Tsoulfa, G., Rook, G. A. W., van Embden, J. D. A., Young, D. B., Mehlert, A., Isenberg, D. A., Hay, F. C. & Lydyard, P. M. (1989) Raised serum IgG and IgA antibodies in mycobacterial antigens in rheumatoid arthritis. Ann. Rheum. Dis. 48, 118. Van Eden, W., Thole, J. E., van der Zee, R., Noordzij, A., van Embden, J. D., Hen Sen B. J & Cohen, I. R. (1988) Cloning of the mycobacterial epitope recognized by T lymphocytes in adjuvant arthritis. Nature 331, 171. Wand-Württenberger, A., Schoel, B., Ivanyi, J. & Kaufmann, S. H. E. (1991) Surface expression by mononuclear phagocytes of an epitope shared with mycobacterial heal shock protein 60. Eur. J. Immunol, (in press). Citing Literature Volume121, Issue1June 1991Pages 67-90 ReferencesRelatedInformation
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