Portal de Periódicos da CAPES

Spectinomycin hydrochloride (Trobicin) in the treatment of gonorrhoea. Observation of resistant strains of Neisseria gonorrhoeae.

1973; BMJ; Volume: 49; Issue: 1 Linguagem: Inglês

10.1136/sti.49.1.54

1472-3263

A Reyn, H Schmidt, Mogens Trier, Michael Weis Bentzon,

Reproductive tract infections research

Treatment of gonorrhoea with penicillin injections is still considered to be the method of choice, as penicillin is both non-toxic and highly effective when given in suitable doses.However, since about 5 per cent. of patients attending venereal disease clinics are allergic to penicillin (Epstein, 1959;Willcox, 1959;Schmidt, 1961), it is important to have several alternatives available.Various injectable antibiotics other than penicillin can be used, in- cluding streptomycin and the tetracyclines, but many strains of gonococci are completely resistant to streptomycin or less sensitive to the tetracyclines.Oral treatment of sexually transmitted diseases has several drawbacks.Patient-to-patient variations in blood levels tend to be greater than in those treated by injection (Schmidt, Roholt, and Larsen, 1967), and patients cannot always be trusted to take their doses correctly.Finally, the patient may be tempted to share his drug with his infected partner, so that both receive inadequate therapy.An injectable aminocyclitol antibiotic, spectinomycin, was isolated in 1960 from Streptomyces spectabilis, and spectinomycin sulphate appeared to be effective in the treatment of gonorrhoea (Laird and Taylor, 1962; Willcox, 1963; Sparling, Yobs, Billings, and Hackney, 1966; Tiedemann, Hackney, and Price, 1965).Recently, the more soluble dihydrochloride salt of spectinomycin has become available commercially in the United States.