Intrathecal Clonidine and Severe Hypotension After Cardiopulmonary Bypass
2003; Lippincott Williams & Wilkins; Linguagem: Inglês
10.1213/01.ane.0000083526.08033.20
ISSN1526-7598
AutoresFerenc Puskás, Enrico M. Camporesi, Colleen E. O Leary, Michael Hauser, Fadi Nasrallah,
Tópico(s)Anesthesia and Pain Management
ResumoIn Brief The use of intrathecal clonidine as an adjunct for the management of chronic pain, intra- and postoperative analgesia is gaining an increase in popularity. However, antinociceptive doses of intrathecal clonidine may produce pronounced hemodynamic side effects, including hypotension and bradycardia. In this report, we present a case of severe hypotension after cardiopulmonary bypass in a patient with intrathecal clonidine infusion. We postulate that the intrathecally administered alpha 2-agonist clonidine reduced our patient’s ability to tolerate the hemodynamic lability that is present during the separation from cardiopulmonary bypass by potentially inhibiting sympathetic nervous system activity, renin-angiotensin system, or vasopressin release. The authors report a case of severe hypotension after cardiopulmonary bypass in a patient receiving intrathecal clonidine infusion for chronic neuropathic pain.
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