An Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme Complex
1997; American Chemical Society; Volume: 40; Issue: 16 Linguagem: Inglês
10.1021/jm970195u
ISSN1520-4804
AutoresAmos B. Smith, Ralph Hirschmann, Alexander Pasternak, Wenyan Yao, Paul A. Sprengeler, M. Katharine Holloway, Lawrence C. Kuo, Zhongguo Chen, Paul L. Darke, William A. Schleif,
Tópico(s)HIV/AIDS drug development and treatment
ResumoADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTAn Orally Bioavailable Pyrrolinone Inhibitor of HIV-1 Protease: Computational Analysis and X-ray Crystal Structure of the Enzyme ComplexAmos B. Smith, Ralph Hirschmann, Alexander Pasternak, Wenquing Yao, Paul A. Sprengeler, M. Katharine Holloway, Lawrence C. Kuo, Zhongguo Chen, Paul L. Darke, and William A. SchleifView Author Information Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Departments of Molecular Design and Diversity, Molecular Biology, and Virus and Cell Biology, Merck Research Laboratories, West Point, Pennsylvania 19486 Cite this: J. Med. Chem. 1997, 40, 16, 2440–2444Publication Date (Web):August 1, 1997Publication History Received24 March 1997Published online1 August 1997Published inissue 1 August 1997https://pubs.acs.org/doi/10.1021/jm970195uhttps://doi.org/10.1021/jm970195urapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views612Altmetric-Citations58LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amides,Crystal structure,Inhibitors,Noncovalent interactions,Peptides and proteins Get e-Alerts
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