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Informatics-guided procurement of patient samples for biomarker discovery projects in cancer research

2008; Springer Science+Business Media; Volume: 10; Issue: 1 Linguagem: Inglês

10.1007/s10561-008-9110-3

1573-6814

K. Stephen Suh, Yvonne Remache, Jalpa S. Patel, Steve H. Chen, Russell Haystrand, Peggy Ford, Anadil M. Shaikh, Jian Wang, André Goy,

Cancer Genomics and Diagnostics

Modern cancer research for biomarker discovery program requires solving several tasks that are directly involved with patient sample procurement. One requirement is to construct a highly efficient workflow on the clinical side for the procurement to generate a consistent supply of high quality samples for research. This undertaking needs a network of interdepartmental collaborations and participations at various levels, including physical human interactions, information technology implementations and a bioinformatics tool that is highly effective and user-friendly to busy clinicians and researchers associated with the sample procurement. Collegial participation that is sequential but continual from one department to another demands dedicated bioinformatics software coordinating between the institutional clinic and the tissue repository facility. Participants in the process include admissions, consenting process, phlebotomy, surgery center and pathology. During this multiple step procedures, clinical data are collected for detailed analytical endpoints to supplement logistics of defining and validating the discovery of biomarkers.