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Succinate: Protective Agent against Hyperbaric Oxygen Toxicity

1965; American Association for the Advancement of Science; Volume: 150; Issue: 3705 Linguagem: Inglês

10.1126/science.150.3705.1830

1095-9203

Aaron P. Sanders, I.H. Hall, Barnes Woodhall,

Pharmacological Receptor Mechanisms and Effects

When succinate is used to protect rats against the toxicity of oxygen at high pressure, 100 percent survive, with normal or above normal concentrations of adenosine triphosphate being present in the cerebral hemisphere, liver, and kidney. In contrast, 90 percent of the nonprotected animals died during exposure. In corresponding tissues of surviving nonprotected animals adenosine triphosphate concentrations are markedly reduced.