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Artigo Produção Nacional Revisado por pares
BIBTEX RIS

Sucralose sweetener in vivo effects on blood constituents radiolabeling, red blood cell morphology and radiopharmaceutical biodistribution in rats

2010; Elsevier BV; Volume: 69; Issue: 1 Linguagem: Inglês

10.1016/j.apradiso.2010.08.009

ISSN

1872-9800

Autores

Gabrielle Souza Rocha, Márcia Oliveira Pereira, Mônica Oliveira Benarroz, Jacques Natan Grinapel Frydman, Vanessa Câmara da Rocha, Mário José dos Santos Pereira, Adenilson de Souza da Fonseca, Aldo Cunha Medeiros, Mário Bernardo-Filho,

Tópico(s)

Ion channel regulation and function

Resumo

Effects of sucralose sweetener on blood constituents labelled with technetium-99m ((99m)Tc) on red blood cell (RBC) morphology, sodium pertechnetate (Na(99m)TcO(4)) and diethylenetriaminepentaacetic acid labeled with (99m)Tc ((99m)Tc-DTPA) biodistribution in rats were evaluated. Radiolabeling on blood constituents from Wistar rats was undertaken for determining the activity percentage (%ATI) on blood constituents. RBC morphology was also evaluated. Na(99m)TcO(4) and (99m)Tc-DTPA biodistribution was used to determine %ATI/g in organs. There was no alteration on RBC blood constituents and morphology %ATI. Sucralose sweetener was capable of altering %ATI/g of the radiopharmaceuticals in different organs. These findings are associated to the sucralose sweetener in specific organs.

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