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The interaction of insecticide synergists with nonenzymatic model oxidation systems

1973; Elsevier BV; Volume: 2; Issue: 4 Linguagem: Inglês

10.1016/0048-3575(73)90055-2

1095-9939

R.S. Marshall, C.F. Wilkinson,

Insect-Plant Interactions and Control

Insecticide synergists such as the 1,3-benzodioxoles, the 1,2,3-benzothiadiazoles and the phenyl-2-propynyl ethers inhibit the epoxidation of aldrin to dieldrin by a modified Fenton's reagent (H2O2, Fe2+, EDTA and bovine serum albumin). Inhibition appears to result from the ability of the synergists to compete with aldrin for the OH· radicals generated by the system, and as a result of this interaction the synergists are themselves chemically modified. In the case of the 1,3-benzodioxoles the reaction results in the formation of the corresponding catechols and the rate at which this occurs correlates favorably with the ability of the synergist to inhibit aldrin epoxidation in the system. Although a number of nonenzymatic systems generating radical species other than OH· are also capable of aldrin epoxidation, these are not affected by the presence of insecticide synergists and the synergists are not themselves modified by these systems. The possible relevance of these results to the mode of action of synergists is discussed.