Increased Alzheimer pathology in Parkinson's disease related to antimuscarinic drugs
2003; Wiley; Volume: 54; Issue: 2 Linguagem: Inglês
10.1002/ana.10639
ISSN1531-8249
AutoresElaine K. Perry, Linda Kilford, Andrew J. Lees, David J. Burn, Robert H. Perry,
Tópico(s)Receptor Mechanisms and Signaling
ResumoAbstract The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer‐type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5‐fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short‐term treated cases ( p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute‐treated groups ( p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients. Ann Neurol 2003
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