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Prevalence of Transmitted HIV-1 Drug Resistance Remains Low in Guangxi, China, Eight Years after Scale-Up of Highly-Active Antiretroviral Therapy

2014; Karger Publishers; Volume: 57; Issue: 5 Linguagem: Inglês

10.1159/000362366

1423-0100

Guojian Li, Shujia Liang, Tim J. Harrison, Zhenzhu Tang, Zhiyong Shen, Xueyan Wang, Xinghua Wu, Wei Liu, Fuxiong Liang, Liushuai Feng, Jin-ye Yang, Zhong‐Liao Fang,

HIV Research and Treatment

<b><i>Objectives:</i></b> Highly-active antiretroviral therapy (HAART) was scaled up in Guangxi, China in 2005. The number of individuals receiving free HAART increased dramatically from June 2010 under the Guangxi Government's anti-HIV programme. We aimed to determine the prevalence of HIV-transmitted drug resistance (TDR) of Guangxi. <b><i>Methods:</i></b> HIV-positive, antiretroviral-naive individuals were recruited from the east (Hezhou), south (Qinzhou), west (Baise), north (Guilin) and centre (Laibin) of Guangxi. The <i>pol</i> gene of the virus from the individuals was analysed. <b><i>Results:</i></b> The overall prevalence of HIV TDR was 3.2% (7/216, 95% CI 0.9-5.5). The prevalence rates in Baise, Guilin, Hezhou, Qinzhou and Laibin are 4.9% (2/41, 95% CI -1.7 to 11.5), 2.3% (1/44, 95% CI -2.1 to 5.7), 4.7% (2/43, 95% CI -1.6 to 11.0), 2.6% (1/38, 95% CI -2.5 to 7.7) and 2.0% (1/50, 95% CI -1.9 to 5.9), respectively. No significant difference in the prevalence was found among them. No factors were found to be associated with TDR, including CD4 cell counts, viral loads and genotypes. The subtypes CRF01_AE, CRF07_BC, CRF08_BC and B were found. Subtype CRF08_BC is the predominant subtype in Baise while CRF01_AE is the predominant subtype elsewhere in Guangxi. <b><i>Conclusions:</i></b> The prevalence of TDR in antiretroviral-naive patients in Guangxi remains low 8 years after scale-up of HAART.