Liver tissue damage by ultrasound in combination with the photosensitizing drug, Photofrin II
1994; Elsevier BV; Volume: 78; Issue: 1-3 Linguagem: Inglês
10.1016/0304-3835(94)90048-5
ISSN1872-7980
AutoresKatsuro Tachibana, Kouichi Sugata, Jing Meng, Makoto Okumura, Shunro Tachibana,
Tópico(s)Effects of Radiation Exposure
ResumoWe have investigated whether ablation of normal rat liver by ultrasound can be enhanced after administration of a photosensitizing agent (Photofrin II). After laparotomy and administration of Photofrin II (30 mg/kg), ultrasound (210 kHz, 1.3 W/cm2) was directed directly to the surface of the liver for a total duration of 3 min by a plane type unfocused transducer (6 mm x 6 mm). The depth of tissue damage was histologically compared to rats exposed to ultrasound alone. The mean maximum lesion depth on rats applied with ultrasound and Photofrin II was 5.7 +/- 0.9 mm (mean +/- SD) whereas in rats treated with ultrasound alone this was 3.0 +/- 0.4 mm. There was a significant difference between the two groups (P < 0.05). The present study suggests the possible use of a photosensitizing agent as an enhancer for the treatment of liver tumors by ultrasound.
Referência(s)