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Association between Cardio-Ankle Vascular Index and Serum Cystatin C Levels in Patients with Cardiovascular Risk Factor

2009; Japan Atherosclerosis Society; Volume: 16; Issue: 4 Linguagem: Inglês

10.5551/jat.no687

1880-3873

Keijiro Nakamura, Takuo Iizuka, M Takahashi, Kazuhiro Shimizu, Hiroshi Mikamo, Takahiro Nakagami, Masayo Suzuki, Keiichi Hirano, Yuko Sugiyama, Takanobu Tomaru, Yoh Miyashita, Kohji Shirai, Hirofumi Noike,

Peripheral Artery Disease Management

The aim of this study was to clarify the relationship between CAVI and serum cystatin C levels to understand the role of arterial stiffness in the presence of renal insufficiency.We enrolled 206 consecutive patients with cardiovascular risk factors and/or coronary artery disease (CAD) in the study. Serum cystatin C, estimated glomerular filtration rate (eGFR), and plasma levels of von Willebrand factor (vWF) and plasminogen activator inhibitor (PAI-1) were measured. CAVI was determined as an index of arterial stiffness.For all patients, the mean serum cystatin C level was 0.81+/-0.21 mg/L and mean eGFR was 65.8+/-15.5 mL/min per 1.73 m(2). In univariate analysis, CAVI levels significantly correlated with cystatin C levels (r=0.414, p<0.001), eGFR (r=-0.315, p<0.01), PAI-1 (r=0.269, p<0.01), and vWF (r=0.207, p<0.01). Multiple regression analysis showed that age, cystatin C, PAI-1, and a history of CAD were independent variables of CAVI. Age-adjusted CAVI was highest in the presence of both CAD and renal impairment.CAVI was closely associated with cystatin C levels. These results suggest a significant role of arterial stiffness in renal insufficiency.