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Guideline for the classification of the acute emetogenic potential of antineoplastic medication in pediatric cancer patients

2011; Wiley; Volume: 57; Issue: 2 Linguagem: Inglês

10.1002/pbc.23114

1545-5017

L. Lee Dupuis, Sabrina Boodhan, Lillian Sung, Carol Portwine, Richard Hain, Patricia McCarthy, Mark T. Holdsworth,

Family and Patient Care in Intensive Care Units

Abstract This guideline provides clinicians caring for children with an approach to assessing the acute emetogenic potential of antineoplastic therapies. It was developed by an international, inter‐professional panel of clinicians and researchers using AGREE and CAN‐ADAPTE methods. The emetogenicity of antineoplastic agents was evaluated and ranked as high, moderate, low, or minimal. The emetogenicity of multiple‐agent and multiple‐day antineoplastic therapy was also classified. Gaps in the evidence used to underpin the guideline recommendations were identified. The contribution of this guideline to the prevention of antineoplastic‐induced nausea and vomiting in individual children about to receive antineoplastic therapy requires prospective evaluation. Pediatr Blood Cancer 2011; 57: 191–198. © 2011 Wiley‐Liss, Inc.