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A Flavo‐Thiazolio‐Cyclophane as a Functional Model for Pyruvate Oxidase

1996; Wiley; Volume: 35; Issue: 12 Linguagem: Inglês

10.1002/anie.199613411

1521-3773

Patrizio Mattei, François Diederich,

Amino Acid Enzymes and Metabolism

The cyclophane 1 is the first functional model for the enzyme pyruvate oxidase in which flavin and thiazolium prosthetic groups are arranged close to a well-defined binding site. It catalyzes the oxidation of 2-naphthaldehyde to methyl 2-naphthoate in MeOH/Et3N with high efficiency and complete reaction selectivity.