Causes of testicular cancer
1997; Volume: 350; Issue: 9081 Linguagem: Inglês
10.1016/s0140-6736(05)62028-4
ISSN0099-5355
Autores Tópico(s)Sexual Differentiation and Disorders
ResumoTesticular cancer is the commonest malignancy in men aged 15–34, and its incidence is rising. 1 Buetow SA Epidemiology of testicular cancer. Epidemiol Rev. 1995; 17: 433-449 PubMed Google Scholar , 2 Stone JM Cruikshank DG Sandeman T et al. Trebling of the incidence of testicular cancer in Victoria, Australia (1950–1985). Cancer. 1991; 68: 211-219 Crossref PubMed Scopus (62) Google Scholar The risk is increased tenfold among those born with undescended testes. 1 Buetow SA Epidemiology of testicular cancer. Epidemiol Rev. 1995; 17: 433-449 PubMed Google Scholar A recent cohort study identified 1075 boys treated for cryptorchidism by orchiopexy and/or hormones at Great Ormond Street Hospital for Sick Children, London, from 1951 to 1964. 3 Swerdlow AJ Higgins CD Pike MC Risk of testicular cancer in cohort of boys with cryptorchidism. BMJ. 1997; 314: 1507-1511 Crossref PubMed Scopus (187) Google Scholar From 1971 to June, 1990. 11 boys were diagnosed with testicular tumours (one bilateral), a relative risk of 7·5 when compared with the number expected. Those most at risk were the 120 who had undergone a testicular biopsy (5 cases diagnosed, 0·08 expected, relative risk 67, 95% CI 24–143), leading A J Swerdlow and colleagues 3 Swerdlow AJ Higgins CD Pike MC Risk of testicular cancer in cohort of boys with cryptorchidism. BMJ. 1997; 314: 1507-1511 Crossref PubMed Scopus (187) Google Scholar to speculate about a causal association between the trauma of an open biopsy and the subsequent development of a testicular cancer.
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