Frequency of functional interleukin-10 promoter polymorphism is different between relapse-onset and primary progressive multiple sclerosis
2002; Elsevier BV; Volume: 63; Issue: 4 Linguagem: Inglês
10.1016/s0198-8859(02)00369-5
ISSN1879-1166
AutoresBrigit A. de Jong, Rudi G. J. Westendorp, Joyce Eskdale, Bernard M.J. Uitdehaag, T. Huizinga,
Tópico(s)Systemic Lupus Erythematosus Research
ResumoInterleukin-10 (IL-10) secretion affects the inducibility of experimental autoimmune encephalomyelitis and the outcome of multiple sclerosis (MS). Here, we report that a G to A polymorphism in the IL-10 promoter at position -2849 is significantly associated with low IL-10 production. The frequency of this polymorphism is lower among patients with primary progressive compared with patients with relapse-onset MS and control persons.
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