Artigo Produção Nacional Revisado por pares

Lethal poisonings with AH-7921 in combination with other substances

2014; Elsevier BV; Volume: 244; Linguagem: Inglês

10.1016/j.forsciint.2014.08.013

ISSN

1872-6283

Autores

Ritva Karinen, Silja Skogstad Tuv, Sidsel Rogde, Mariana Dadalto Peres, Unni Johansen, Joachim Frost, Vigdis Vindenes, Åse Marit Leere Øiestad,

Tópico(s)

Opioid Use Disorder Treatment

Resumo

AH-7921 is a synthetic μ-opioid agonist, approximately equipotent with morphine. We report the death of two young individuals after ingestion of AH-7921 in combination with other psychoactive drugs. In the first case a young man died shortly after ingesting Internet drugs. Toxicological analysis of post mortem peripheral blood revealed AH-7921 (0.43 mg/L), 2-FMA (0.0069 mg/L) and 3-MMC (0.0021 mg/L) as well as codeine (0.42 mg/L), codeine-6-glucuronide (0.77 mg/L) and acetaminophen (18.7 mg/L). The second case involved a young female found dead at home. The only positive finding at medicolegal autopsy was needle marks. Toxicological analysis revealed AH-7921 (0.33 mg/L), methoxetamine (MXE) (0.064 mg/L), etizolam (0.27 mg/L), phenazepam (1.33 mg/L), 7-aminonitrazepam (0.043 mg/L), diazepam (0.046 mg/L), nordiazepam (0.073 mg/L), and oxazepam (0.018 mg/L) in blood. In both cases intoxication with AH-7921 in combination with other psychoactive drugs was considered to be the cause of death.

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