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Oxidative stress in ecotoxicology: from the analysis of individual antioxidants to a more integrated approach

2002; Elsevier BV; Volume: 54; Issue: 3-5 Linguagem: Inglês

10.1016/s0141-1136(02)00146-0

1879-0291

Francesco Regoli, Stefania Gorbi, Giada Frenzilli, Marco Nigro, Ilaria Corsi, Silvano Focardi, Gary W. Winston,

Pesticide and Herbicide Environmental Studies

An integrate approach will be discussed for investigations on oxidative stress in xenobiotic toxicity. While the analysis of individual antioxidants is useful for their sensitivity and to understand the mode of action of a stressor, the integration with the analysis of the total antioxidant capacity provides a more holistic assessment of the overall biological significance of such variations. TOSC has a greater predictive value on the health condition of the organisms and allows to discriminate the different role of specific ROS in oxidative stress syndrome.