4-Acyl-5-hydroxy-1-phenyl-3-trifluoromethylpyrazoles: Synthesis and NMR Spectral Investigations
2006; Elsevier BV; Volume: 68; Issue: 9 Linguagem: Inglês
10.3987/com-05-10502
ISSN1881-0942
AutoresWolfgang Hölzer, Sabine Bieringer,
Tópico(s)Synthesis and Characterization of Heterocyclic Compounds
ResumoThe title compounds were prepared by reaction of 1-phenyl-3-trifluoromethyl-1H-pyrazol-5-ol with trimethyl orthoacetate, triethyl orthopropionate and triethyl orthobenzoate, respectively, followed by hydrolytic cleavage of the primarily formed condensation products.Detailed NMR spectroscopic investigations with the obtained products are presented, revealing the title compounds to be present as 5-hydroxypyrazoles stabilized by an intramolecular hydrogen bond in CDCl 3 solution.
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