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The Use of Alkylating Agents in the Treatment of Wegener's Granulomatosis

1967; American College of Physicians; Volume: 67; Issue: 2 Linguagem: Inglês

10.7326/0003-4819-67-2-393

1539-3704

Daniel Hollander,

Sarcoidosis and Beryllium Toxicity Research

Case Studies1 August 1967The Use of Alkylating Agents in the Treatment of Wegener's GranulomatosisDANIEL HOLLANDER, M.D., ROBERT T. MANNING, M.D., F.A.C.P.DANIEL HOLLANDER, M.D., ROBERT T. MANNING, M.D., F.A.C.P.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-67-2-393 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptWegener's granulomatosis, a rare disease of unknown etiology, was first described by Klinger (1) in 1931. Wegener (2), in 1936, reported three additional patients, recognizing the syndrome as a distinct clinicopathological entity. He believed it to be related to periarteritis nodosa.Clinically, Wegener's granulomatosis is characterized by necrotizing granulomatous lesions of the upper or lower respiratory tract, generalized necrotizing angiitis involving both arteries and veins, and focal necrotizing glomerulonephritis (3).Antibiotics (4), adrenocorticosteroids (5), and radiotherapy (4, 6) have been used in the management of this disorder. The average survival time of patients is 5 months, the most common causes...References1. KLINGER H: Grenzformen der periarteritis nodosa. Frankfurt. Z. Path. 42: 455, 1931. Google Scholar2. WEGENER F: Über generalisierte, septische Gefässerkrankungen. Verh. Deutsch. Ges. Path. 29: 202, 1936. Google Scholar3. GODMANCHURG GCJ: Wegener's granulomatosis; pathology and review of literature. Arch. Path. (Chicago) 58: 533, 1954. MedlineGoogle Scholar4. WALTON WE: Giant-cell granuloma of the respiratory tract (Wegener's granulomatosis). Brit. Med. J. 2: 265, 1958. CrossrefMedlineGoogle Scholar5. FREDLYNCHGREENBERGGONZALEZ-ANGULO HLECSDA: A patient with Wegener's granulomatosis exhibiting unusual clinical and morphological features. Amer. J. Med. 37: 311, 1964. CrossrefMedlineGoogle Scholar6. MERRILL MD: Roentgen therapy in Wegener's granulomatosis. Amer. J. Roentgen. 85: 96, 1961. Google Scholar7. AUNGSTLESSMANN CWEM: Wegener's granulomatosis treated with nitrogen mustard. New York J. Med. 62: 3302, 1962. MedlineGoogle Scholar8. MCILVANIE SK: Wegener's granulomatosis; successful treatment with chlorambucil. JAMA 197: 90, 1966. CrossrefMedlineGoogle Scholar9. FAHEYLEONARDCHURGGODMAN JLEJG: Wegener's granulomatosis. Amer. J. Med. 17: 168, 1954. CrossrefMedlineGoogle Scholar10. TUHYMAURICENILES JEGLNR: Wegener's granulomatosis. Amer. J. Med. 25: 638, 1958. CrossrefMedlineGoogle Scholar11. BERMANRYDELLEICHENHOLZ DAREA: Wegener's granulomatosis. A clinico-pathologic study of four cases. Ann. Intern. Med. 59: 521, 1963. LinkGoogle Scholar12. EVANSHALLEY DWJB: Wegener's granulomatosis: a report of a patient surviving four and a half years. J. Clin. Path. 16: 215, 1963. CrossrefMedlineGoogle Scholar13. KINNEYOLSENHEPPERHARRISON VRAMNGEG: Wegener's granulomatosis. Report of two cases and brief review. Arch. Intern. Med. (Chicago) 108: 159, 1961. CrossrefGoogle Scholar14. SHARNOFFSCHNEIDER JGL: Wegener's granulomatosis. Amer. Rev. Resp. Dis. 86: 553, 1962. MedlineGoogle Scholar15. STERNBERGREYNOLDSZEILENGA THJRH: Pathergic granulomatosis. Report of two cases formerly designated Wegener's granulomatosis and malignant granuloma of the face. Arch. Derm. (Chicago) 75: 368, 1957. Google Scholar16. TYNER GS: Wegener's granulomatosis: a case report. Amer. J. Ophthal. 50: 1203, 1960. CrossrefMedlineGoogle Scholar17. LINDHOLMNILSSON HS: Wegener's granulomatosis (a survey and a report on six cases). Acta Rheum. Scand. 4: 102, 1958. CrossrefMedlineGoogle Scholar18. JOHNSONDAUGHTRY UDC: Wegener's granulomatosis. Case report; antemortem diagnosis and observations on effect of treatment. Amer. Pract. Dig. Treatm. 10: 46, 1959. MedlineGoogle Scholar19. BORLEYMILLER WEWW: Wegener's granulomatosis. Trans. Amer. Acad. Ophthal. 65: 316, 1961. Google Scholar20. MCDONALDEDWARDS JBRW: "Wegener's granulomatosis"—a triad. JAMA 173: 1205, 1960. CrossrefGoogle Scholar21. READTREIP AECS: Wegener's granulomatosis. Granuloma of the nose with systemic polyarteritis nodosa. Postgrad. Med. J. 33: 199, 1957. CrossrefMedlineGoogle Scholar22. STRATTONPRICESKELTON HJTMMO: Granuloma of the nose and periarteritis nodosa. Brit. Med. J. 1: 127, 1953. CrossrefMedlineGoogle Scholar23. Case records of the Massachusetts General Hospital (case 87-1961). New Eng. J. Med. 265: 1156, 1961. Google Scholar24. ZIMMERMANSTRAUS HNB: Clinicopathologic conference: widely disseminated granulomatous disorder. New York J. Med. 61: 920, 1961. Google Scholar25. MACFADYEN DJ: Wegener's granulomatosis with discrete lung lesions and peripheral neuritis. Canad. Med. Ass. J. 83: 760, 1960. MedlineGoogle Scholar26. MOORE W: A case of Wegener's granulomatosis in Uganda. Tubercle 42: 355, 1961. CrossrefMedlineGoogle Scholar27. CARRINGTONLIEBOW CBAA: Limited forms of angiitis and granulomatosis of Wegener's type. Amer. J. Med. 41: 497, 1966. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Kansas City, KansasFrom the Department of Medicine, University of Kansas Medical Center, Kansas City, Kan.Requests for reprints should be addressed to Daniel Hollander, M.D., Department of Medicine, University of Washington, Seattle, Wash. 98105. 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