Phospholipase Cγ1 is essential for T cell development, activation, and tolerance
2010; Rockefeller University Press; Volume: 207; Issue: 2 Linguagem: Inglês
10.1084/jem.20090880
ISSN1540-9538
AutoresGuoping Fu, Yuhong Chen, Mei Yu, Andy Podd, James Schuman, Yinghong He, Lie Di, Maryam Yassai, Dipica Haribhai, Paula E. North, Jack Gorski, Calvin B. Williams, Demin Wang, Renren Wen,
Tópico(s)Protein Kinase Regulation and GTPase Signaling
ResumoPhospholipase Cγ1 (PLCγ1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCγ1 in T cell biology, we generated and examined mice with T cell–specific deletion of PLCγ1. We demonstrate that PLCγ1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-κB. Importantly, PLCγ1 deficiency impairs the development and function of FoxP3+ regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCγ1 is essential for T cell development, activation, and tolerance.
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