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Module assemblage technology for floating systems: In vitro flotation and in vivo gastro-retention

2008; Elsevier BV; Volume: 129; Issue: 2 Linguagem: Inglês

10.1016/j.jconrel.2008.04.015

1873-4995

Orazio Luca Strusi, Fabio Sonvico, Ruggero Bettini, Patrizia Santi, Gaia Colombo, Pedro Barata, Ana Oliveira, Delfim Santos, Paolo Colombo,

Pickering emulsions and particle stabilization

The aim of this research was to study, in vitro by resultant-weight measurement and in vivo by γ-scintigraphy experiments in humans, the floatation behavior of systems obtained by modules assembled in void configuration. The assembled system technology allowed the manufacturing of a system characterized by the presence of an internal void space that provided an apparent density lower than water. The gastro-retention times of floating assembled systems were determined in comparison with non-floating systems having the same mass and composition. In vitro the floatation of the system started immediately after immersion in water and lasted for more than 5 h. The in vivo studies confirmed that the in vitro floating ability of void configuration was maintained also in the human stomach where the system stayed for periods of time ranging from 2.5 to 5.0 h, depending on the food regimen and the sex of the subject. Reiterate eating and drinking further prolonged the stomach residence time.