Evidence that substance P and somatostatin transmit separate information related to pain in the spinal dorsal horn
1985; Elsevier BV; Volume: 325; Issue: 1-2 Linguagem: Inglês
10.1016/0006-8993(85)90326-9
ISSN1872-6240
AutoresYasushi Kuraishi, Naoyoshi Hirota, Yoichi Sato, Yutaka Hino, Masamichi Satoh, Hiroshi Takagi,
Tópico(s)Myofascial pain diagnosis and treatment
ResumoEffects of various types of natural skin stimuli on the in situ release of immunoreactive substance P and somatostatin from the rabbit dorsal horn were examined. Noxious mechanical or thermal stimuli specifically increased the release of immunoreactive substance P or somatostatin, respectively. Innocuoss stimuli did not affect the release of these peptides. These results suggest that the nociceptive mechanical or thermal primary afferents contain substance P or somatostatin, respectively.
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