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Influence of glycemic control on Epstein-Bar and Cytomegalovirus infection in periodontal pocket of type 2 diabetic subjects

2010; Elsevier BV; Volume: 55; Issue: 11 Linguagem: Inglês

10.1016/j.archoralbio.2010.07.009

1879-1506

Renato Corrêa Viana Casarin, Poliana Mendes Duarte, Vanessa Renata Santos, Jadson Almeida Lima, Guy Gagnon, Márcio Zaffalon Casati, Reginaldo Bruno Gonçalves,

Salivary Gland Disorders and Functions

The aim of the present study was to evaluate the influence of glycemic control on the frequency of Epstein-Bar (EBV) and Cytomegalovirus (CMV) in periodontal pockets of type 2 diabetic subjects with chronic periodontitis. Forty-six subjects presenting generalized chronic periodontitis and type 2 diabetes mellitus (DM) were selected for this study. Polymerase chain reaction (PCR) was used to determine the presence of EBV and CMV in shallow [Probing Depth (PD) ≤ 3 mm], moderate (PD = 4–6 mm) and deep (PD > 7 mm) pockets. HbA1c levels ≤7%, >7 to <10%, and ≥10% defined good, moderate and poor glycemic control, respectively. Higher frequency of EBV was found in the shallow pockets of the subjects with poor glycemic control (p < 0.05; chi-square test). Moreover, EBV-free subjects presented moderate or good glycemic control. Glycemic control did not influence the frequency of CMV in all pocket categories. Poor glycemic control in type 2 diabetic subjects can increase the occurrence of EBV in shallow periodontal pockets.