Portal de Periódicos da CAPES

Connective tissue biology and hepatic fibrosis: Report of a conference

1990; Lippincott Williams & Wilkins; Volume: 11; Issue: 3 Linguagem: Inglês

10.1002/hep.1840110322

1527-3350

Montgomery D. Bissell, Scott L. Friedman, Jacquelyn J. Maher, Jon T. Roll,

Genetic factors in colorectal cancer

HepatologyVolume 11, Issue 3 p. 488-498 Special ArticleFree Access Connective tissue biology and hepatic fibrosis: Report of a conference Dr. D. Montgomery Bissell, Corresponding Author Dr. D. Montgomery Bissell Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Liver Center Laboratory, Buliding 40, Room 4102, San Francisco Genral Hospital San Francisco, CA 94110===Search for more papers by this authorScott L. Friedman, Scott L. Friedman Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this authorJacquelyn J. Maher, Jacquelyn J. Maher Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this authorF. Joseph Roll, F. Joseph Roll Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this author Dr. D. Montgomery Bissell, Corresponding Author Dr. D. Montgomery Bissell Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Liver Center Laboratory, Buliding 40, Room 4102, San Francisco Genral Hospital San Francisco, CA 94110===Search for more papers by this authorScott L. Friedman, Scott L. Friedman Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this authorJacquelyn J. Maher, Jacquelyn J. Maher Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this authorF. Joseph Roll, F. Joseph Roll Liver Core Center, University of California and Medicial Service, San Francisco General Hospital San Francisco, CA 94110Search for more papers by this author First published: March 1990 https://doi.org/10.1002/hep.1840110322Citations: 99AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL References 1 Burgeson RE. New Collagens, new concepts. Annu Rev Cell Biol 1988; 4: 551– 577. 2 Bissell DM, Roll FJ. Connective tissue metabolism and hepatic fibrosis. In: D Zakim, TD Boyer eds. Hepatology, 2nd Ed. Philadelphia: W. B. Sauders Co., 1989; 424– 444. 3 Rojkind M, Pince-Noyola P. The extraellular matrix of the liver. Coll Relat Res 1982; 2: 151– 175. 4 Hahn EG, Schuppan D. Ethanol and fibrogenesis in the liver. In: HK Seitz, B Kommerell eds. Alcohol related diseases in gastroenterology. Baerlin: Springer-Verlag, 1985: 124– 153. 5 Timpl R. Structure and biological activity of basement membrane proteins. Eur J Biochem 1989; 180: 487– 502. 6 Saus J, Wieslander J, Langevelf JPM, Quinones S, Hudson BG. Identification of the Goodpasture antigen as the alpha3(IV) chain of collagen IV. J Bioll Chem 1988; 26: 13374– 13380. 7 Miyahara M, Hayshi K, Berger J, Tanzawa K, Njieha FK, Trelstad RL, Prockop DJ. Formation of collagen fibrils by enzynic cleavage of precursors of type I collagen in vitro. J Biol Chem 1984; 259: 9891– 9898. 8 Bissell DM, Arenson DM, Maber JJ, Roll FJ. Support of cultured hepatocytes by a laminin-rich gel: evidence for a funtionally significant subendothel matrix in normal rat liver. J Clin Invest 1987; 79: 801– 812. 9 Hassell JR, Kimura JH, Hascall VC. Proteoglucan core protein families. Annus Rev Biochem 1986; 55: 539– 567. 10 Poole AR. Proteoglycans in health and disease: structures and functions. Biochem J 1986; 236: 1– 14. 11 Gallagher JT, Lyon M, Steward WP. Structure and function of heparan sulpahte proteoglcans. Biochem J 1986; 236: 313– 325. 12 Kjellen L, Oldberg A, Hook M. Cell-surface heparan sulfate:mechanisms of proteoglycan-cell association. J Biol Chem 1980; 108: 255: 10407– 10413. 13 Sunders S, Jalkanen M, O'Farrell S, Bernfield M. Molecular cloning of syndecan: an integral membrane proteoglycan. J Cell Biol 1989; 108: 1547– 1556. 14 Hayashi K, Hayashi M, Jalkanen M, Firestone JH, Trelstad RL, Bernfield M. Immunicytochemistry of cell surface heparan sulfate proteoglycanin mouse tissues: a light and eletron microscopic study. J Histochem Cytochem 1987.; 35: 1079– 1088. 15 Ruoslahti E. Structure and biology of proteoglycans. Annu Rev Cell Biol 1988; 4: 229– 255. 16 Caterson B, Christner JE, Baker JR, Couchman JR. Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans. Fed Proc 1985; 44: 386– 393. 17 Dziadek M, Clements R, Mitrangas K, Reiter H, Fowler K. Analysis of degradation of the basement membrane protein nidogen, using a specific monoclinal antibody. Eur J Biochem 1988; 172: 219– 225. 18 Hynes RO. Fibronectins: a family of complex and versatile adhesive glycoproteins derived form a single gene. Harvey Lect 1987; 81: 133– 152. 19 Oh E, Peirschbacher M, Ruoslahti E. Deposition of plsma fibronection in tissues. Proc Natl Acad Sci USA 1981; 78: 3218– 3221. 20 Ramadori G, Rieder H, Knittel Th, Dineses HP, Meyer zum Büschenfelde K. Fat-stroring cells (FSC) of rat liver synthesize and secrete fibronectin. J Hepatol 1987; 4: 190– 197. 21 Orrego H, Medline A, Blendis LM, Rankin JG, Kreaden DA. Collagenation of the Disse space in alcoholcic liver disease. Gut 1979; 20: 673– 678. 22 Guzelian PS, Gureshi GD, Diegelamann RF. Colagen synthesis by hepatocyte: studies in primary cultures of parenchymal cells from adult rat lover. Coll Relat Res 1981; 1: 83– 93. 23 Hata R-I, Ninomoya Y, Sano J, Konomi H, Hori H, Suanada H, Tanaka S, et al. Activation of collagen synthesis in primary culture of rat liver parenchymal cells (hepatocytes). J Cell Physiol 1985; 122: 333– 342. 24 Clement B, Laurent M, Guguen-Guillouzo C, Lebeau G, Guillouzo A. Types I and IV procollagen gene expresion in cultured rat hepatocytes. Coll Relat Res 1988; 8: 349– 359. 25 Maher JJ, Bissell DM, Friedman SL, Roll FJ. Collagen measured in primary cultures of normal rat hepatocytes derives from lipocytes within the monolayer. J Clinc Invest 1988; 82: 450– 459. 26 Friedman SL, Roll JF, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 1985.; 82: 8681– 8685. 27 Arenson DM, Friedman SL, Bissell DM. Formation of extracellular matrix in normal rat liver: lipocytes as a major source of proteoglycan. Gastroenterology 1988; 95: 441– 447. 28 Schaefer S, Zerbe O, Gessner AM. The synthesis of proteoglycans in fat-storing cells of rat liver. HEPATOLOGY 1987; 7: 680– 687. 29 Gressner AM, Haarman R. Hyaluronic acid synthesis and secretion by rat liver fat storing cells (perisinusoidal lipocytes) in culture. Biochem Biophys Res Commun 1988; 151: 222– 229. 30 Murata K, Ochiai Y, Akashio K. Polydispersity of acidic glycosaminoglycan components in human liver and the changes at different stages in liver cirrhosis. Gasroenterology 1985; 89: 1248– 1257. 31 Clement B,. Rescan PY, Baffet G, Loreal O, Lehry D, Campion JP, Gullouzo A. Hepatocytes may produce laminin in fibrotic liver and in primary culture. HEPATOLOGY 1988; 8: 794– 803. 32 Rescan P-Y, Clement B, Grimaud J-A, Buillois B, Strain A, Guillouzo A. Participation of hepatocytes in the production of basement membrane components in human and rat liver during the perinatal period. Cell Differ Dev 1989; 26: 131– 144. 33 Eyken PV, Sciot R, Desmet V. Intraphepatic bile duct development in the rat: a cytokeratin-immunohistochemical study. Lab Invest 1988; 59: 52– 59. 34 Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situhybrization for procolangen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells. HEPATOLOGY 1989; 10: 84– 92. 35 Chojkier M. Hepatocyte collagen production in vivo in normal rats. J Clin Invest 1986; 78: 333– 339. 36 Chojkier M, Lyche KD, Filip M. Increased production of collagen in vivo by hepatocytes and nonparenchymal cells in rats with carbon tetrachloride–induced hepatic fibrosis. HEPATOLOGY 1988; 8: 803– 814. 37 Rojkind M, Gatmaitan Z, Mackensen S, Giambrone MA, Ponce P, Ried LM. Connective tissue biomatrix: its isolation and utilization for long-term cultures of normal rat hepatocytes. J Cell Biol 1980; 87: 255– 263. 38 Gullberg D, Terracio L, Borg TK, Rubing K. Identification of integirn-like matrix receptors with affinity for interstital collagens. J Biol Chem 1989; 264: 12686– 12694. 39 Clement B, Segui-Real B, Hassell JR, Martin GR, Yamada Y. Identification of a cell surface–binding protein for the core protein of the basemet membrane proteoglycan. J Biol Chem 1989; 264: 12467– 12471. 40 Graf J, Iwamoto Y, Sasaki. Martin GRE, Kleinman HK, Robey FA, Yamamda Y. Identification of an amino acid sequence in laminin mediating cell attachment, chemotaxis, and receptor binding. Cell 1987; 48: 989– 996 41 Kleinman HK, Sephel GC, Tashiro KI, Weeks BS, Burrous BA, Adler SH, Yamada Y, et al. Laminin in neuronal development NY Acad Sci [in press]. 42 Kleinman HK, Ebihara I, Killen PD, Sasaki M, Cannon FB, Yamada Y, Martin GR. Genes for basment membrane proteins are coordinately expressed in differentiating F9 cells but not in normal adult murine tissues. Dev Biol 1987; 122: 373– 378. 43 Ekblom P. Developmentally regulated conversion of mesenchyme to epithelium. FASEB J 1989; 3: 2141– 2150. 44 Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunilocallization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 1988.; 94: 1053– 1062. 45 Hunter DD, Shah V, Merlie JP, Sanes JR. A laminin-like adhesive protein concentrated in the synaptic cleft of the neuromuscular junction. Nature 1989; 338: 229– 233. 46 Fujita M, Spray DC, Choi H, Saez JC, Watanabe T, Rosenberg LC, Hertzberg EL, et al. Glycosaminoglycan and proteoglycans induce gap junction expression and restore transcription of tissue-specific mRNSAs primary liver cultures. HEPATOLOGY 1987.; 7: 1S– 9S. 47 Ishihara M, Fedarko NS, Conrad HE. Transport of heparan sulfate into the nuclei of hepatocytes. J Biol Chem 1986; 262: 13575– 13580. 48 Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differetniated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Bioll Chem 1989; 264: 10756– 10762. 49 Carley WW, Milici AJ, Madri JA. Extracellular matrix specificity for the differnctiation of capillary endothelial cells. Exp Cell Res 1988; 178: 426– 434. 50 Ruoslahti E, Pierschbacher MC. New perspectives in cell adhesion: RGD and integrins, Science 1987; 238: 491– 497. 51 Greenwel P, Saed SO, Rojkind M. Clona hetertogeneity of cirrhotic rat liver fibroblasts Abstract. HEPATOLOGY 1988; 8: 1307. 52 Roberts AB, Sporn MB, Assoian RK, Smith JM, Rohche NS, Wakefield LM, Heine UI et al. Transforming growth factor type beta: rapid induction of fibrosis and angiongenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci USA 1986; 83: 4167– 4171. 53 Weiner FR, Czaja MJ, Jefferson DM, Giambrone M-A, TurKaspa R, Reid LM, Zern MA. The effects of dexamethasone on in vitro collagen gene expression, J Biol Chem 1987; 262: 6955– 6958. 54 Rosenbloom J, Feldman G, Freundlich B, Jimenez SA. Transcriptional control of human diploid fibroblast collgen synthesis by gamma-intefeorn. Biochem Biophys Res Commun 1984; 123: 365– 372. 55 Solis-Herruzo JA, Brenner DA, Chojkier M. Tumor necrosis factor alpha inhibits colagen gene transcription and collagen syntheis in cultured human fibroblasts. J Biol Chem 1988; 263: 5841– 5845. 56 Horlein D, McPherson J, Goh SH, Bornstein P. Regulation of protein synthesis: translational control by procollagen-derved gragments. Proc Natl Acad Sci USA 1981; 78: 6163– 6167. 57 Wu CH, Walton CM. Propetide regualtion of procollagen syntheis: evidence for a transcriptional site of action [Abstract]. HEPATOLOGY 1987; 7: 1047 58 Matsuoka M, Pham NT, Tsukamoto H. Differential effects of interleukin-1-alpha, tumor necrosis factor alpha, and transforming growth beta-1 on cell proliferation and collagen formation by cultured fat-storint cells. Liver 1989; 9: 71– 78. 59 Braun L, Mead JF, Panzica M, Mikumo R, Bell GI, Fausto N. Transforming growth factor beta mRNA increases during liver regenration: a possible paracrine mechanism of growth regulation. Proc Natl Acad Sci USA 1988; 85: 1539– 1543. 60 Strain AJ, Frazer A, Hill DJ, Milner RDG. Transforming growth factor beta inhibits DNA synthesis in hepatocytes isolated from normal and regenerating rat liver. Biochem Biophys Res Commun 1987; 145: 436– 442. 61 Weiner FR, Giambrone MA, Takahashi S, Annoni G, Czaja MJ, Zern MA. Modulators of Ito cell collagen synthesis [Abstract]. HEPATOLOGY 1988; 8: 1253. 62 Davis BH. Tranforming growth factor beta responsiveness is modulated by the exreaellular collagen matrix during hepatic Ito cell culture. J Cell Physiol 1988; 136: 547– 553. 63 Davis BH, Vucic A. Modulation of vitamin A metabolism during hepatic and intestinal cell culture. Biochim Biophys Acta 1989; 1010: 318– 324. 64 Shiratori Y, Ichida T, Geerts A, Wisse E. Moduclation of collagen synthesis by fat-storing cells, isolated from CC14- or vitamin A–treated rats Dig Dis Sci 1987; 32: 1281– 1289. 65 Lyons RM, Keski-Oja J, Moses HL. Proteolytic activation of latent transfroming growth factor-beta from fibroblast conditioned medium. J Cell Biol 1659– 1665. 66 Yokoi Y, Namishisa T, Matsuzaki K, Miyazaki A, Yamaguchi Y. Distribution of Ito cells in experimental hepatic fibrosis. Liver 1988; 8: 48– 52. 67 French SW, Miyamoto K, Wong K, Jui L, Breire L. Role of the Ito cell in liver parenchymal fibrosis in rats fed alcophol and a high fat-low protein diet. Am J Pathol 1988; 132: 61– 73. 68 Horn T, Junge J, Chirstoffersen P. Early alcoholic and a high fat-low protein diet. Am J Pathol 1988; 132: 61– 73. 69 DeLeeuw AM, Sp McCarthy Geerts A, Knook D. Purified rat liver fat-storing cells in culture divided and contain collagen. HEPATOLOGY 1984; 4: 392– 403. 70 Skalli O, Gabbini G. The biology of the myofibroblast relationship to wound contracrtion and fivrocontractive diseases. In In: RAF Clark, PM Henson eds. The molecular and cellular biology of wound repair. New York and London: Plenum Press 1988; 373– 402. 71 Rudolph R, McClure WJ, Woodward M. Contractilie fibroblasts in chronc alciholic cirrhosis. Gastroenterology 1979; 76: 704– 709. 72 Nakano M, Worner TM, Lieber CS. Perivenular fibrosis in alcoholoc liver injury: ultrastructure and histologic progression. Gasteoenterlogy 1982; 83: 777– 785. 73 Ballardini G, Esposti SD, Bianchi FB, DeGiogi LB, Faccani A, Biolchini L, Busachi A, et al. Correlation between Ito cells and fibrogenesis in an experimental model of hepatic fibrosis: a sequential stereological study. Liver 1983; 3: 58– 63. 74 Mak KM, Leo MA, Lieber CS. Alcoholic liver injury in baboons: transfromation of lipocytes to transitional cells. Gastroenterolgy 1984; 4: 709– 714. 75 Yokoi Y, Namihisa T, Kuroda H, Komatsu I, Miyazuki A, Watanabe S, Usui K. Immunocytchemical detection of desmin in fat-storing cells (Ito cells). HEPATOLOGY 1984; 4: 709– 714. 76 Takase S, Leo MA, Nouchi T, Lieber CS. Desmin distinguishe culturedfat-storing cells from myofibroblasts, smooth muscel cells and fibroblasts in the rat. J Hapatol 1988; 6: 267– 276. 77 Shiratori Y, Geerts A, Ichida T, Kawase T, Wisse E. Kupffer cells form CC14-induced fibrotic livers stimulate proliferation of fat-storing cells. J Hepatol 1986; 3: 294– 303. 78 Gressner AM, Zerbe O. Kupffer cell –mediated induction of synthesis and secretion of proteoglycans by rat liver fat-storing cells in culture. J Hepatol 1987; 5: 299– 310. 79 Gressner AM, Harrmann R. Regualtion of hyaluranate synthesis in rat liver fater storing cell cultures by Kupffer cells. J Hepatol 1988; 7: 310– 318. 80 Armendarizborunda J, Greenwel P, Rojkind M. Kupffer cells form CC14-treated rat livers induce skin fibroblast and liver fat-stroing cell proliferation in culture. Matrix 1989; 9: 150– 158. 81 Friedman SL, Arthur MJP. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium: direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 1989; 84: 1780– 1785. 82 Choe I, Aycock RS, Raghow R, Myers JC, Seyer JM, Kang AH. A hepatic fibrogenci factor stimulates the synthsis of types I, III, and V procollagens in cultured cells. J Biol Chem 1987; 262: 5408– 5413. 83 Krischeke H, Kembhavi AA, Bohley P, Barrett AJ. Action of rat liver cathspsin L on collaen and other substrates. Biochem J 1982; 201: 367– 372. 84 Brenner DA, O'Hara M,. Angel P, Chojkier M, Karin M. Prolonged activation of jun and collagenase genes by tumor necrosis factor-alpha. Narure 1989; 337: 661– 663. 85 Angel P, Baumann L, Stein B, Delius H, Rahmsdorf HJ, Herrlich P. 12-0-tetradecanoyul-phorbol-13-acetate (TPA) induction of the human collagenase gene is mediated by an inducible enhancer element located inthe 5′-flanking region. Mol Cell Biol 1987; 7: 2256– 2266. 86 Lindblad WJ, Fuller GC. Hepatic colalgenase activity during carbon tetrachiloride induced fibrosis. Fund Appl Toxicol 1983; 3: 34– 40. 87 Stetler-Stevenson WG, Krutzsch HC, Wacher MP, Margulies IMK, Liotta LA. The activation of human type IV collagenase proenzyme. J Biol Chem 1989; 264: 1353– 1356. 88 Arthur MJP, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 1989; 84: 1076– 1085. 89 Andus T, Ramadori G, Henrich PC, Knittel T, Meyer zum Büschemfelde K. Cultured Ito cells of rat liver express the alpha2-macroglobulin gene. Eur J Biochem 1987; 168: 641– 646. 90 Campbell EJ, Cury JD, Lazarus CJ, Welgus HG. Monocyte procellagenase and tissue inhibitor of metalloproteinases. J Biol Chem 1987; 262: 15862– 15868. 91 Clark SD, Kobayashi DK, Welgus HG. Regulation of the expression of tissue inhibitor of metalloproteinases and collagenase by retinoids and glucocorticoids in human fibroblasts. J Clin Invest 1987; 80: 1280– 1288. 92 Banda MJ, Rice AG, Griffin GL, Senior RM. The inhibitory complex of human alpha 1-proteinase inhibitor and human leukocyte elastase is a neutrophil chemoattractant. J Exp Med 1988; 167: 1608– 1615. 93 Gruber BL, Marchese MJ, Susuki K, Schwartz LB, Okada Y, Nagase H, Ramamurthy NS. Synovial procollagenase activation by human mast cell tryptase: dependence upon matrix metalloproteinase 3 activation. J Clin Invest 1989; 84: 1657– 1662. 94 Tsukamoto H, Towner SJ, Ciofalo LM, French SW. Ethanol induced liver fibrosis in rats fed high fat diet. HEPATOLOGY 1986; 6: 814– 822. 95 Prakash S, Dinarello CA, Danko K, Stadecker MJ, Wyler DJ. Schistosomal egg granuloma-derived fibroblast-stimulating factor is apparently distinct from interleukin-1. Infect Immun 1989; 57: 679– 684. 96 Czaja MJ, Weiner FR, Giambrone MA, Wind R, Zern MA. The in vitro and in vivo association of transforming growth factor beta with hepatic fibrosis. J Cell Biol 1989; 108: 2477– 2482. 97 Wahl SM. Fibrosis: bacterial -cell-wall-induced hepatic granulomas. In: JI Gallin, IM Goldstein, R Snyderman, eds. Inflammation: basic principles and clinical correlates. New York: Raven Press, Ltd., 1988; 841– 860. 98 Wahl SM, Hunt DA, Wakefield LM, McCartney-Francis N, Wahl LM, Roberts AB, Sporn MB. Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci USA 1987; 84: 5788– 5792. 99 Goldberg GI, Wilhelm SM, Kronberger A, Bauer EA, Grant GA, Eisen AZ. Human fibroblast collagenase. J Biol Chem 1986; 261: 6600– 6605. 100 Hasty KA, Jeffrey JJ, Hibbs MS, Welgus HG. The collagen substrate specificity of human neutrophil collagenase. J Biol Chem 1987; 262: 10048– 10052. 101 Murphy G, McAlpine CG, Poll CT, Reynolds JJ. Purification and characterization of a bone metalloproteinase that degrades gelatin and types IV and V collagen. Biochem Biophys Acta 1985; 831: 49– 58. 102 Hibbs MS, Hoidal JR, Kang AH. Expression of a metalloproteinase that degrades native type V collagen and denature collagens by cultured human alveolar macrophages. J Clin Invest 1987; 80: 1644– 1650. 103 Bejarano PA, Noelken ME, Suzuki K, Hudson BG, Nagase H. Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin). Biochem J 1988; 256: 413– 149. 104 Ott U, Odermatt E, Engel J, Furthmayr H, Timpl R. Protease resistance and conformation of laminin. Eur J Biochem 1982; 123: 63– 72. 105 Vissers MCM, Winterbourn CC. Gelatinase contributes to the degradation of glomerular basement membrane collagen by human neutrophils. Coll Relat Res 1988; 8: 113– 122. 106 Woodbury RG, Everitt MT, Neurath H. Mast cell proteases. Methods Enzymol 1981; 80: 588– 609. Citing Literature Volume11, Issue3March 1990Pages 488-498 ReferencesRelatedInformation