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Fecal Blood Loss Following Aspirin and Coated Aspirin Microspherule Administration

1968; Wiley; Volume: 8; Issue: 6 Linguagem: Inglês

10.1002/j.1552-4604.1968.tb00109.x

2375-0839

Eugene P. Frenkel, Mary Sue McCall, Charles C. Douglass, Seymour Eisenberg,

Case Reports on Hematomas

The Journal of Clinical Pharmacology and The Journal of New DrugsVolume 8, Issue 6 p. 347-351 Fecal Blood Loss Following Aspirin and Coated Aspirin Microspherule Administration EUGENE P. FRENKEL M.D., EUGENE P. FRENKEL M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Frenkel is Acting Chief, Radioisotope Service and Consultant in Hematology & Cancer Chemotherapy, Veterans Administration Hospital, and Associate Professor and Chief Hematology & Cancer Chemotherapy Section, Dept. of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas.Search for more papers by this authorMARY SUE McCALL B.S., MARY SUE McCALL B.S. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Miss Mccall is Assistant Chief, Radioisotope Service, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this authorCHARLES C. DOUGLASS M.D., CHARLES C. DOUGLASS M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Douglass was Resident in Department of Medicine, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this authorSEYMOUR EISENBERG M.D., SEYMOUR EISENBERG M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Eisenberg is Chief of the Medical Service, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this author EUGENE P. FRENKEL M.D., EUGENE P. FRENKEL M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Frenkel is Acting Chief, Radioisotope Service and Consultant in Hematology & Cancer Chemotherapy, Veterans Administration Hospital, and Associate Professor and Chief Hematology & Cancer Chemotherapy Section, Dept. of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas.Search for more papers by this authorMARY SUE McCALL B.S., MARY SUE McCALL B.S. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Miss Mccall is Assistant Chief, Radioisotope Service, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this authorCHARLES C. DOUGLASS M.D., CHARLES C. DOUGLASS M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Douglass was Resident in Department of Medicine, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this authorSEYMOUR EISENBERG M.D., SEYMOUR EISENBERG M.D. Radioisotope Service, Veterans Administration Hospital, and the Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas. Dr. Eisenberg is Chief of the Medical Service, Veterans Administration Hospital, Dallas, Texas.Search for more papers by this author First published: November‐December 1968 https://doi.org/10.1002/j.1552-4604.1968.tb00109.xCitations: 4 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References 1 Leonards, J. R., and Levy, G.: Absorption and metabolism of aspirin administered in enteric-coated tablets. J.A.M.A. 193: 99 (1965). 2 Green, D. M.: Tablets of coated aspirin microspherules—a new dosage form. J. New Drugs 6: 294 (1966). 3 Douthwaite, A. H., and Lintott, G. A. M.: Gastroscopic observation of effect of aspirin and certain other substances on the stomach. Lancet 2: 1222 (1938). 4 Hurst, A., and Lintott, G. A. M.: Aspirin as cause of haematemesis: clinical and gastroscopic study. Guy's Hosp. Rep. 89: 173 (1939). 5 Douthwaite, A. H.: Effect of aspirin on the stomach. Lancet 2: 917 (1954). 6 Weiss, A., Pitman, E. R., and Graham, E. C.: Aspirin and gastric bleeding. Amer. J. Med. 31: 266 (1961). 7 Muir, A., and Cossar, I. A.: Aspirin and ulcer. Brit. Med. J. 2: 7 (1955). 8 Muir, A., and Cossar, I. A.: Aspirin and gastric hemorrhage. Lancet 1: 539 (1959). 9 Schneider, E. M.: Aspirin as a gastric irritant. Gastroenterol. 33: 616 (1957). 10 Lange, H. F.: Salicylates and gastric hemorrhage. I. Occult bleeding. Gastroenterol. 33: 770 (1957). 11 Stubbe, L. T.: Occult blood in faeces after administration of aspirin. Brit. Med. J. 2: 1062 (1958). 12 Stubbe, L. T., Pietersen, J. H., and Van Heulen, C.: Aspirin preparations and their noxious effect on the gastro-intestinal tract. Brit. Med. J. 1: 675 (1962). 13 Roche, M., Perez-Gimenez, M. E., Layrisse, M., and Diprisco, E.: Study of urinary and fecal excretion of radioactive chromium Cr51 in man. Its use in the measurement of intestinal blood loss associated with hookworm infection. J. Clin. Invest. 36: 1183 (1957). 14 Anderson, E. T., Passovoy, M., and Trobaugh, F. E., Jr.: Quantitation of gastrointestinal bleeding by use of a large volume scintillation detector. J. Nuclear Med. 7: 612 (1966). 15 Matsumoto, K. K., and Grossman, M. I.: Quantitative measurement of gastrointestinal blood loss during ingestion of aspirin. Proc. Soc. Exper. Biol. Med. 102: 517 (1959). 16 Porter, I. H., Lewis, M., and Dixon, A. St. J.: Salicylate therapy and faecal blood loss (in summary). Ann. Rheum. Dis. 18: 62 (1959). 17 Holt, P. R.: Measurement of gastrointestinal blood loss in subjects taking aspirin. J. Lab. Clin. Med. 56: 717 (1960). 18 Pierson, R. N., Jr., Holts, P. R., Watson, R. M., and Keating, R. P.: Aspirin and gastrointestinal bleeding. Amer. J. Med. 31: 259 (1961). 19 Leonards, J. R.: Aspirin and gastrointestinal blood loss. Gastroenterol. 44: 617 (1963). 20 Dixon, A. St. J., Scott, J. T., and Harvey-Smith, E. A.: Aspirin and the anaemia of rheumatoid arthritis. Brit. Med. J. 1: 1425 (1960). 21 Wood, P. H., Harvey-Smith, E. P., and Dixon, A. S.: Salicylates and gastrointestinal bleeding. Acetylsalicyclic acid and aspirin derivatives. Brit. Med. J. 1: 669 (1962). 22 Wood, P. H., and Wilson, C. H., Jr.: Iron-deficiency anemia in rheumatoid arthritis, and the role of aspirin-induced gastrointestinal bleeding in its pathogenesis. Arthritis Rheum. 7: 354 (1964). 23 Roth, J. L. A., Valdes-Dapena, A., Pieses, P., and Buchman, E.: Topical action of salicylates in gastrointestinal erosion and hemorrhage. Gastroenterol. 44: 146 (1963). 24 Grossman, M. I., Matsumoto, K. K., and Lichter, R. J.: Fecal blood loss produced by oral and intravenous administration of various salicylates. Gastroenterol. 40: 383 (1961). Citing Literature Volume8, Issue6November‐December 1968Pages 347-351 ReferencesRelatedInformation