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Zoledronic acid in metastatic chondrosarcoma and advanced sacrum chordoma: two case reports

2009; BioMed Central; Volume: 28; Issue: 1 Linguagem: Inglês

10.1186/1756-9966-28-7

1756-9966

Liliana Montella, Raffaele Addeo, Vincenzo Faiola, Gregorio Cennamo, Rosario Guarrasi, Elena Capasso, Rosanna Mamone, Michele Caraglia, Salvatore Del Prete,

Sarcoma Diagnosis and Treatment

Chondrosarcomas and chordomas are usually chemoresistant bone tumors and may have a poor prognosis when advanced. They are usually associated with worsening pain difficult to control. Zoledronic acid was used in a 63-year-old man with metastatic chondrosarcoma and in a 66-year-old woman with a diagnosis of sacrum chordoma both reporting severe pain related to tumor. In the first case, zoledronic acid was able to maintain pain control despite disease progression following chemotherapy, in the other case, zoledronic acid only produced significant clinical benefit. Control of pain associated with bone tumors such as chondrosarcoma and chondroma may significantly improve from use of zoledronic acid, independently from tumor response to other treatments. Evaluation on larger series are needed to confirm the clinical effect of this bisphosphonate on such tumors.