Produção Nacional
Revisado por pares
SIMULTANEOUS OCCURRENCE OF ADVANCED NEUROBLASTOMA AND ACUTE MYELOID LEUKEMIA
2001; Taylor & Francis; Volume: 18; Issue: 2 Linguagem: Inglês
10.1080/088800101300002964
ISSN1521-0669
AutoresTelma M. Santos-Machado, Maria Cláudia Nogueira Zerbini, L Cristofani, P. Azevedo, Maria T. A. Almeida, Paulo T. Maluf, Vicente Odone Filho,
Tópico(s)Acute Myeloid Leukemia Research
ResumoThe authors report the case of a 4-year-old boy with a diagnosis of stage IV neuroblastoma (NB), who had been treated with 6 cycles of cyclophosphamide, doxorubicin, cisplatin, and etoposide for 12 months. The patient reached partial remission and presented a diagnosis of acute myelomonocytic leukemia (M4 AML), confirmed by immunophenotyping. After 2 months of therapy for leukemia, the child died with both malignancies in activity. A necropsy histologically confirmed the simultaneity of the two diseases. The authors review the possibilities of this association. The review leads to the conclusion that AML can occur as a secondary malignancy after the onset of the neuroblastoma, or be suggested by a misdiagnosis. The simultaneous occurrence of both as described here is not, however, found in the literature, to the best of the authors' knowledge.
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