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DOSAGE EFFECTS AND INDIVIDUAL RESPONSIVITY TO METHYLPHENIDATE IN ATTENTION DEFICIT DISORDER

1988; Wiley; Volume: 29; Issue: 4 Linguagem: Inglês

10.1111/j.1469-7610.1988.tb00737.x

1469-7610

V. I. Douglas, Ronald G. Barr, Khanda Ali Hama Amin, Maureen E. O'Neill, B. G. Britton,

Neurotransmitter Receptor Influence on Behavior

Abstract Effects of three dosages of methylphenidate (0.15, 0.30 and 0.60 mg/kg) were assessed in 19 ADD‐H children on a variety of cognitive, academic and behavioral measures in the laboratory and the classroom. A predominant linear pattern of improvement was found across almost all measures. A slight decrease between 0.3 and 0.6 mg/kg on one cognitive task leaves open the possibility that higher dosages reduce stimulant effectiveness or cause decrements on some kinds of “high‐level/high load” tasks. Response patterns of individual children varied considerably across measures. All children improved on at least several measures. Results were interpreted as evidence for stimulant activation of self‐regulatory processes.