Enigma of fetal/infant-origins hypothesis
1996; Elsevier BV; Volume: 348; Issue: 9037 Linguagem: Inglês
10.1016/s0140-6736(05)65750-9
ISSN1474-547X
AutoresMichael S. Kramer, K.S. Joseph,
Tópico(s)Birth, Development, and Health
ResumoDavid Barker and his colleagues at the University of Southampton have, during a decade of prolific epidemiological research, investigated the hypothesis that coronary heart disease (CHD) and several other chronic adult diseases have their origins in fetal and infant life. This intriguing hypothesis, and the original and creative work it has spawned, have brought a breath of fresh air to both perinatal and cardiovascular disease epidemiology. Influence of fathers' social class on cardiovascular disease in middle-aged menFather's social class is strongly associated with adult social class. The higher risk of non-fatal myocardial infarction and self-reported physician-diagnosed ischaemic heart disease seen in men whose father's social class was manual suggests that socioeconomic status early in life has some persisting influence on ischaemic heart disease risk in adult life. Full-Text PDF Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UKStroke may originate in poor nutrition during the mother's childhood, which deforms the bony pelvis and subsequently impairs her ability to sustain the growth of the placenta and fetus in late pregnancy. Coronary heart disease, on the other hand, seems to originate in adaptations made by the fetus to inadequate delivery of nutrients when it occurs for reasons other than failure of placental growth. Full-Text PDF Fetal growth and coronary heart disease in South IndiaIn India, as in the UK, coronary heart disease is associated with small size at birth, suggesting that its pathogenesis is influenced by events in utero. The association with low maternal bodyweight is further evidence that the disease originates through fetal undernutrition. Prevention of the rising epidemic of the disease in India may require improvements in the nutrition and health of young women. Full-Text PDF
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