The characterization of serum lipoproteins from portacaval shunted Macaca fasicularis monkeys
1979; Academic Press; Volume: 22; Issue: 1 Linguagem: Inglês
10.1016/0006-2944(79)90043-7
ISSN1557-7996
AutoresCharles A. Nelson, Robert E. Casali, Manford D. Morris,
Tópico(s)Cardiovascular Disease and Adiposity
ResumoThe serum lipoproteins of Macaca fasicularis monkeys subjected to portacaval shunts were compared to those of sham-operated on both chow and cholesterol-fat diets. On either diet, only the HDL (high-density lipoprotein) cholesterol levels were found to be significantly different between sham-operated and shunted monkeys. The HDL cholesterol of the shunted were a third lower on the chow diet (P < .025) and 50% lower on the cholesterol diet (P < .005) by both direct isolation of the VLDL, LDL, and HDL lipoprotein components and by heparin-manganese precipitation measurements of the HDL remaining in the supernatant of serum previously assayed for total cholesterol. This decrease in HDL occurred in only the HDL2 fraction (d < 1.125 g/ml), the HDL3 remaining constant. The proportion of faster floating LDL (low-density lipoproteins) was increased for cholesterol-fed shunted monkeys over the sham-operated at all levels of LDL cholesterol (comparing only groups equivalent in LDL cholesterol).
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