Prevalence and Correlates of Self-Reported Pretransplant Nonadherence with Medication in Heart, Liver, and Lung Transplant Candidates
2005; Wolters Kluwer; Volume: 79; Issue: 11 Linguagem: Inglês
10.1097/01.tp.0000158430.06507.87
ISSN1534-6080
AutoresFabienne Dobbels, Johan Vanhaecke, Ariane Desmyttere, Lieven Dupont, Frederik Nevens, Sabina De Geest,
Tópico(s)Pharmacological Effects and Toxicity Studies
ResumoEvidence on prevalence and correlates of pretransplant medication nonadherence (MNA) is limited. The present study explored self-reported prevalence and correlates of MNA before heart, liver, and lung transplantation.This cross-sectional descriptive study included 174 patients: 69 lung, 33 heart, and 72 liver transplant candidates. MNA was assessed by self-report using the following question: "During the past 14 days, how often did you not take your medication?" Patients scoring once or higher on a five-point rating scale were considered to be nonadherent. Correlates of MNA explored were demographics, anxiety and depression (Hospital Anxiety and Depression Inventory), personality traits (NEO Personality Inventory-Revised), perceived health status (Euro-QOL), and social support (Social Support Questionnaire).Prevalence of pretransplant MNA was 16.7% and was comparable among the three groups. After correction for multiple comparisons (i.e., P=0.01), higher educational level (P=0.006) was related to MNA. Less severe depression (P=0.069), lower scores on the personality trait conscientiousness (P=0.021), and less received social support (P=0.062) tended to be related to MNA. Multiple logistic regression revealed that higher educational level (P=0.008), lower received social support (P=0.013), and lower conscientiousness (P=0.023) were independent predictors of pretransplant MNA.Several correlates of MNA allow identification of patients at risk for pretransplant MNA.
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