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THE EFFECTS OF PHENFORMIN ON PERIPHERAL GLUCOSE UTILIZATION AND INSULIN ACTION IN OBESITY AND DIABETES MELLITUS *

1968; Wiley; Volume: 148; Issue: 3 Linguagem: Inglês

10.1111/j.1749-6632.1968.tb27744.x

1749-6632

W. J. H. Butterfield,

Metabolism, Diabetes, and Cancer

Annals of the New York Academy of SciencesVolume 148, Issue 3 p. 724-733 THE EFFECTS OF PHENFORMIN ON PERIPHERAL GLUCOSE UTILIZATION AND INSULIN ACTION IN OBESITY AND DIABETES MELLITUS* W. J. H. Butterfield, W. J. H. Butterfield Guy's Hospital Medical School London, EnglandSearch for more papers by this author W. J. H. Butterfield, W. J. H. Butterfield Guy's Hospital Medical School London, EnglandSearch for more papers by this author First published: March 1968 https://doi.org/10.1111/j.1749-6632.1968.tb27744.xCitations: 29 * This investigation was supported in part by research grants from the Medical Research Council, the British Insulin Manufacturers, the Wellcome Foundation, and the Governors of Guy's Hospital. AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat References Butterfield, W. J. H. 1964. Peripheral action of insulin and its relation to the aetiology of diabetes mellitus. Ciba Found. Colloq. Endocrinol. 15: 250–270. CASGoogle Scholar Butterfield, W. J. H. 1965. In On the Nature and Treatment of Diabetes. Leibel Wrenshall.: 768. Excerpta Medica Foundation, Amsterdam , the Netherlands . Google Scholar Butterfield, W. J. H. 1966. Oliver Sharpey Lecture. To be published. Google Scholar Butterfield, W. J. H. and M. E. Abrams and D. J. B. St. John and M. J. Whichelow 1967. The intravenous glucose tolerance test: Peripheral disposal of the glucose load in controls and diabetics. Metabolism 16: 19. 10.1016/0026-0495(67)90155-2 CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H., J. Camp, C. Hardwick & H. E. Holling 1957. Clinical studies of the hypoglycaemic action of the sulphonylureas. Lancet 1: 753. 10.1016/S0140-6736(57)91023-1 Web of Science®Google Scholar Butterfield, W. J. H., C. J. Garratt & M. J. Whichelow 1962. Peripheral hormone action: A method for the study of the action of insulin in the forearm tissues. Guy'sHosp. Rep. 111: 130. CASPubMedGoogle Scholar Butterfield, W. J. H., C. J. Garratt & M. J. Whichelow 1963. Peripheral hormone action: Studies on the clearance and effect of [131I] iodo-insulin in the peripheral tissues of normal, acromegalic and diabetic subjects. Clin. Sci. 24: 331. CASWeb of Science®Google Scholar Butterfield, W. J. H., T. Hanley & M. J. Whichelow 1965. Peripheral metabolism of glucose and free fatty acids during oral glucose tolerance tests. Metabolism 14: 851. 10.1016/0026-0495(65)90122-8 CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H. & H. E. Holling 1959. Peripheral glucose metabolism in fasting control subjects and diabetic patients. Clin. Sci. 18: 147. CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H., I. Kelsey Fry and M. J. Whichelow 1961. The hypoglycae-mic action of phenformin. Studies in diabetics after short-term therapy. Lancet 2: 563. 10.1016/S0140-6736(61)90520-7 CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H. and M. J. Whichelow 1962. The hypoglycaemic action of phenformin. Effect of phenformin on glucose metabolism in peripheral tissues. Diabetes 11: 281. CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H. & M. J. Whichelow 1964. Are thyroid hormones diabetogenic? A study of peripheral glucose metabolism during glucose infusions in normal subjects and hyperthyroid patients before and after treatment. Metabolism 13: 620. 10.1016/0026-0495(64)90070-8 CASPubMedWeb of Science®Google Scholar Butterfield, W. J. H. & M. J. Whichelow 1965. Peripheral glucose metabolism in control subjects and diabetic patients during glucose, glucose-insulin and insulin sensitivity tests. Diabetologia 1: 43. 10.1007/BF01338715 CASGoogle Scholar Butterfield, W. J. H. & M. J. Whichelow. To be published. Google Scholar Dettwyler, W. & W. J. H. Butterfield 1964. Mechanisme d'action de la phenethyl-biguanide. Diabete 12: 229. CASPubMedGoogle Scholar Mottram, R. F. & W. J. H. Butterfield 1961. The human forearm as a preparation for metabolic investigations. Proc. Roy. Soc. Med. 54: 549. Web of Science®Google Scholar Rabinowitz, D. & K. L. Zierler 1962. Role of free fatty acids in forearm metabolism in man, quantitated by use of insulin. J. Clin. Invest. 41: 2191. 10.1172/JCI104678 CASPubMedWeb of Science®Google Scholar Citing Literature Volume148, Issue3Diabetes Mellitus and Obesity: Phenformin Hydrochloride as a Research ToolMarch 1968Pages 724-733 ReferencesRelatedInformation