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Urinary PGE2concentrations measured by a new EIA method in infants with urinary tract infections or renal malformations

2001; Elsevier BV; Volume: 64; Issue: 6 Linguagem: Inglês

10.1054/plef.2001.0279

1532-2823

Laura Cuzzolin, P. Mangiarotti, Vassilios Fanos,

Acute Kidney Injury Research

In this work PGE(2)concentrations were measured by a new EIA method in the urine of infants (mean age: 9.35+/-4.24 months) with recurrent urinary tract infections or renal malformations. Compared to healthy subjects, PGE(2)excretion rates resulted significantly higher in both pathological groups, in particular in subjects with obstructive uropathies (29.55+/-8.12 vs 18.37+/-4.64 pg/ml). We did not find any age- or pH-dependent difference in urinary excretion of PGE(2); none of the examined indices of renal function showed any significant relationship to PGE(2). These results suggest that this parameter, measured non-invasively in the urine, could help in the differential diagnosis between obstructive vs non-obstructive dilatation and in monitoring renal function in presence of recurrent UTI episodes.