Produção Nacional
Revisado por pares
Blockage of dopaminergic D2 receptors produces decrease of REM but not of slow wave sleep in rats after REM sleep deprivation
2008; Elsevier BV; Volume: 188; Issue: 2 Linguagem: Inglês
10.1016/j.bbr.2007.11.025
ISSN1872-7549
Autores Tópico(s)Sleep and related disorders
ResumoDopamine (DA) has, as of late, become singled out from the profusion of other neurotransmitters as what could be called a key substance, in the regulation of the sleep–wake states. We have hypothesized that dopaminergic D2 receptor blockage induced by haloperidol could generate a reduction or even an ablation of rapid eye movement (REM) sleep. Otherwise, the use of the selective D2 agonist, piribedil, could potentiate REM sleep. Electrophysiological findings demonstrate that D2 blockage produced a dramatic reduction of REM sleep during the rebound (REB) period after 96 h of REM sleep deprivation (RSD). This reduction of REM sleep was accompanied by an increment in SWS, which is possibly accounted for the observed increase in the sleep efficiency. Conversely, our findings also demonstrate that the administration of piribedil did not generate additional increase of REM sleep. Additionally, D2 receptors were found down-regulated, in the haloperidol group, after RSD, and subsequently up-regulated after REB group, contrasting to the D1 down-regulation at the same period. In this sense, the current data indicate a participation of the D2 receptor for REM sleep regulation and consequently in the REM sleep/SWS balance. Herein, we propose that the mechanism underlying the striatal D2 up-regulation is due to an effect as consequence of RSD which originally produces selective D2 supersensitivity, and after its period probably generates a surge in D2 expression. In conclusion we report a particular action of the dopaminergic neurotransmission in REM sleep relying on D2 activation.
Referência(s)