Portal de Periódicos da CAPES

Candida and Host Determinants of Susceptibility to Invasive Candidiasis

2013; Public Library of Science; Volume: 9; Issue: 1 Linguagem: Inglês

10.1371/journal.ppat.1003079

1553-7374

Michail S. Lionakis, Mihai G. Netea,

Neutrophil, Myeloperoxidase and Oxidative Mechanisms

How Does the Innate Immune System Recognize Candida?The first step in mounting an effective anti-Candida immune response is fungal recognition by the innate immune system.Over the past decade there has been an explosion in our understanding of how soluble and membrane-bound pattern recognition receptors (PRRs) recognize various pathogen-associated molecular patterns (PAMPs) of Candida yeast and filamentous forms (Text S1) (reviewed in [11,12]).In brief, the complement components C3 and C5, the complement receptor 3 (CR3), the Toll-like receptors (TLR)-2 (in interaction with TLR1 and TLR6), TLR4, TLR7, and TLR9, and the C-type lectins (CLRs) dectin-1, dectin-2, mannose receptor, DC-SIGN, and Mincle are among the PRRs shown to recognize different fungal PAMPs including mannan, bglucan, RNA, and DNA (Figure 1); several of these PRRs are indispensable for host defense in vivo by inducing the secretion of pro-inflammatory cytokines and chemokines and modulating