Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis
2003; Wiley; Volume: 53; Issue: 6 Linguagem: Inglês
10.1002/ana.10597
ISSN1531-8249
AutoresIlias G. Kirkinezos, Dayami Hernandez, Walter G. Bradley, Carlos T. Moraes,
Tópico(s)Parkinson's Disease Mechanisms and Treatments
ResumoAbstract We tested whether a regular exercise regimen was associated with a change in the life span of G93A‐SOD1 transgenic mice, a model of familial ALS. Regular treadmill running for 10 weeks led to a significant increase in the life span of G93A‐SOD1 mice. The effect was stronger in male mice, whereas there was only a trend between exercised and sedentary female G93A‐SOD1 mice. The data suggest that regular exercise has a beneficial effect on the progression of ALS. Ann Neurol 2003;53:804–807
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