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Antinociceptive effect and acute toxicity of the essential oil of Hyptis fruticosa in mice

2007; Elsevier BV; Volume: 78; Issue: 3 Linguagem: Inglês

10.1016/j.fitote.2006.11.020

1873-6971

Igor Alexandre Côrtes de Menezes, Maxsuel S. Marques, Thiago C. Santos, Kellyane S. Dias, Aline B.L. Silva, Iderjane C.M. Mello, Ana C.C.D. Lisboa, Péricles Barreto Alves, Sócrates C.H. Cavalcanti, Rosilene M. Marçal, Ângelo R. Antoniolli,

Alkaloids: synthesis and pharmacology

The essential oil of the Hyptis fruticosa leaves was analyzed by GC/MS and evaluated for antinociceptive property as well as acute toxicity in mice. The essential oil, at doses of 100, 200, and 400 mg/kg (s.c.), produced significant inhibition of acetic acid-induced writhing, but did not manifest a significant effect in hot-plate test. There was no acute toxicity at doses up to 5 g/kg. Bicyclogermacrene, 1,8-cineole, α-pinene, and β-caryophyllene were the major compounds detected in the essential oil.