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Estimation of performance characteristics of a confirmation method for thyreostats in plasma by means of a weighted least-squares approach

2007; Elsevier BV; Volume: 592; Issue: 2 Linguagem: Inglês

10.1016/j.aca.2007.04.026

1873-4324

Panagiotis Steliopoulos, Eberhard Stickel,

Analytical Methods in Pharmaceuticals

A weighted linear regression-based approach was applied to ascertain analytical performance characteristics of a method for the quantitative determination of thyreostats in plasma by LC–MS. The weights were set equal to the reciprocal of the variances. A straightforward and practical procedure is presented that was used to model the variance of the replicate measurements as a function of concentration. Different function types were tested for their suitability.