Produção Nacional
Revisado por pares
Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans
2013; Nature Portfolio; Volume: 4; Issue: 1 Linguagem: Inglês
10.1038/ncomms2656
ISSN2041-1723
AutoresPaul Brotherton, Wolfgang Haak, Jennifer E.L. Templeton, Guido Brandt, Julien Soubrier, Christina Adler, Stephen M. Richards, Clio Der Sarkissian, Robert Ganslmeier, Susanne Friederich, Veit Dresely, Mannis van Oven, Rosalie Kenyon, Mark B. Van der Hoek, Jonas Korlach, Khai Luong, Simon Y. W. Ho, Lluís Quintana‐Murci, Doron M. Behar, Harald Meller, Kurt W. Alt, Alan Cooper, Syama Adhikarla, Arun Kumar Ganesh Prasad, Ramasamy Pitchappan, Arun Varatharajan Santhakumari, Elena Balanovska, Oleg Balanovsky, Jaume Bertranpetit, David Comas, Begoña Martínez‐Cruz, Marta Melé, Andrew Clarke, Elizabeth Matisoo‐Smith, Matthew C. Dulik, Jill B. Gaieski, Amanda C. Owings, Theodore G. Schurr, Miguel G. Vilar, Angela Hobbs, Himla Soodyall, Asif Javed, Laxmi Parida, Daniel E. Platt, Ajay K. Royyuru, Jin Li, Shilin Li, Matthew E. Kaplan, Nirav Merchant, R. John Mitchell, Colin Renfrew, Daniela R. Lacerda, Fabrício R. Santos, David F. Soria Hernanz, R. Spencer Wells, Pandikumar Swamikrishnan, Chris Tyler‐Smith, Pedro Paulo Vieira, Janet Ziegle,
Tópico(s)Archaeology and ancient environmental studies
ResumoHaplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this ‘real-time’ genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria. Here, Brotherton and colleagues sequence 39 mitochondrial genomes from ancient human remains. They track population changes across Central Europe and find that the foundations of the European mitochondrial DNA pool were formed during the Neolithic rather than the post-glacial period.
Referência(s)