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An efficient conversion of 1-abietic acid to (+)−3-deoxyaphidicolin

1985; Elsevier BV; Volume: 26; Issue: 22 Linguagem: Inglês

10.1016/s0040-4039(00)98137-1

1873-3581

Hiroo Koyama, Hideki Okawara, Susumu Kobayashi, Masaji Ohno,

Plant-derived Lignans Synthesis and Bioactivity

Abstract The first total synthesis of (+)−3-deoxyaphidicolin, a selective inhibitor of eukaryotic DNA polymerase α, has been completed efficiently and stereoselectively starting from 1-abietic acid.