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Severe Rhabdomyolysis Related to Cerivastatin without Gemfibrozil

2002; American College of Physicians; Volume: 137; Issue: 1 Linguagem: Inglês

10.7326/0003-4819-137-1-200207020-00028

1539-3704

David J. Hyman, Andrea Henry, Addison A. Taylor,

Cardiac Imaging and Diagnostics

Letters2 July 2002Severe Rhabdomyolysis Related to Cerivastatin without GemfibrozilDavid J. Hyman, MD, MPH, Andrea Henry, PharmD, and Addison Taylor, MDDavid J. Hyman, MD, MPHHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this author, Andrea Henry, PharmDHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this author, and Addison Taylor, MDHarris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-137-1-200207020-00028 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:The hydroxymethylglutaryl coenzyme A reductase inhibitors (“statins”) decrease serum cholesterol levels and morbidity and mortality from coronary heart disease. Although these drugs are well tolerated, serious adverse effects may occur. All members of this class may cause rhabdomyolysis, particularly when combined with gemfibrozil.We report six cases of severe rhabdomyolysis in patients taking cerivastatin without concomitant gemfibrozil. The patients were symptomatic (creatine kinase levels >5000 U/L) and were hospitalized with no other clear causes of rhabdomyolysis (Table). The cases occurred among approximately 3000 patients exposed to the drug for about 9 months. All six patients described here ... Author, Article, and Disclosure InformationAffiliations: Harris County Hospital District; Houston, TX 77030 (Hyman, Henry, Taylor) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byMeasures of Disease FrequencyCa2+-Releasing Effect of Cerivastatin on the Sarcoplasmic Reticulum of Mouse and Rat Skeletal Muscle Fibers 2 July 2002Volume 137, Issue 1Page: 74KeywordsCreatine kinaseDatabasesDrugsHealth careHospital medicineMorbidityMortalityPrevention, policy, and public healthRhabdomyolysisStatins ePublished: 2 July 2002 Issue Published: 2 July 2002 Copyright & PermissionsCopyright © 2002 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...