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What is the Potential of syndecan-4-targeted Novel Delivery technologies?

2013; Future Science Ltd; Volume: 4; Issue: 12 Linguagem: Inglês

10.4155/tde.13.112

2041-6008

László Szilák, Tamás Letoha, Bettina Ughy,

Dendrimers and Hyperbranched Polymers

Therapeutic DeliveryVol. 4, No. 12 EditorialWhat is the potential of syndecan-4-targeted novel delivery technologies?Laszlo Szilak, Tamas Letoha & Bettina UghyLaszlo Szilak* Author for correspondenceInstitute of Biology, University of West Hungary, Savaria University Centre, Szombathely, Hungary and CEO Szilak Laboratories Ltd, Szeged, Hungary. , Tamas LetohaPharmacoidea Ltd, Szeged, Hungary & Bettina UghyBiological Research Centre, HAS, Szeged, HungaryPublished Online:5 Dec 2013https://doi.org/10.4155/tde.13.112AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInRedditEmail View articleKeywords: cytoplasmic targetdrug deliveryendocytosis heparan sulfate proteoglycannuclear localizationreceptorretrograde transportsyndecan-4References1 Mayor S, Pagano RE. Pathways of clathrin-independent endocytosis. Nat. Rev. Mol. Cell Biol.8(8),603–612 (2007).Crossref, Medline, CAS, Google Scholar2 Hutagalung AH, Novick PJ. Role of Rab GTPases in membrane traffic and cell physiology. Physiol. Rev.91(1),119–149 (2011).Crossref, Medline, CAS, Google Scholar3 Kopatz I, Remy JS, Behr JP. A model for non-viral gene delivery: through syndecan adhesion molecules and powered by actin. J. Gene Med.6(7),769–776 (2004).Crossref, Medline, CAS, Google Scholar4 ur Rehman Z, Sjollema KA, Kuipers J, Hoekstra D, Zuhorn IS. Nonviral gene delivery vectors use syndecan-dependent transport mechanisms in filopodia to reach the cell surface. ACS Nano6(8),7521–7532 (2012).Crossref, Medline, Google Scholar5 Letoha T, Keller-Pintér A, Kusz E et al. Cell-penetrating peptide exploited syndecans. Biochim. Biophys. Acta1798(12),2258–2265 (2010).Crossref, Medline, CAS, Google Scholar6 Letoha T, Kolozsi C, Ekes C et al. Contribution of syndecans to lipoplex-mediated gene delivery. Eur. J. Pharm. Sci.49(4),550–555 (2013).Crossref, Medline, CAS, Google Scholar7 Paris S, Burlacu A, Durocher Y. Opposing roles of syndecan-1 and syndecan-2 in polyethyleneimine-mediated gene delivery. J. Biol. Chem.283(12),7697–7704 (2008).Crossref, Medline, CAS, Google Scholar8 Montrose K, Yang Y, Sun X, Wiles S, Krissansen GW. Xentry, a new class of cell-penetrating peptide uniquely equipped for delivery of drugs. Sci. Rep.3,1661 (2013).Crossref, Medline, CAS, Google Scholar9 Yoo J, Jeong MJ, Cho HJ, Oh ES, Han MY. Dynamin II interacts with syndecan-4, a regulator of focal adhesion and stress-fiber formation. Biochem. Biophys. Res. Commun.328(2),424–431 (2005).Crossref, Medline, CAS, Google Scholar10 Hayashida K, Stahl PD, Park PW. Syndecan-1 ectodomain shedding is regulated by the small GTPase Rab5. J. Biol. Chem.283(51),35435–35444 (2008).Crossref, Medline, CAS, Google Scholar11 Zimmermann P, Zhang Z, Degeest G et al. Syndecan recycling is controlled by syntenin-PIP2 interaction and Arf6. Dev. Cell.9(3),377–388 (2005).Crossref, Medline, CAS, Google Scholar12 Tkachenko E, Lutgens E, Stan RV, Simons M. Fibroblast growth factor 2 endocytosis in endothelial cells proceed via syndecan-4-dependent activation of Rac1 and a Cdc42-dependent macropinocytic pathway. J. Cell Sci.117(15),3189–3199 (2004).Crossref, Medline, CAS, Google Scholar13 Keller-Pinter A, Bottka S, Timar J et al. Syndecan-4 promotes cytokinesis in a phosphorylation-dependent manner. Cell Mol. Life Sci.67(11),1881–1894 (2010).Crossref, Medline, CAS, Google Scholar101 Szilak Laboratories Bioinformatics and Molecule-Design Ltd: WO/2008/010162 (2008).Google ScholarFiguresReferencesRelatedDetailsCited ByContribution of Syndecans to the Cellular Entry of SARS-CoV-219 May 2021 | International Journal of Molecular Sciences, Vol. 22, No. 10Contribution of syndecans to cellular internalization and fibrillation of amyloid-β(1–42)4 February 2019 | Scientific Reports, Vol. 9, No. 1Contribution of syndecans to cellular uptake and fibrillation of α-synuclein and tau12 November 2019 | Scientific Reports, Vol. 9, No. 1 Vol. 4, No. 12 Follow us on social media for the latest updates Metrics Downloaded 67 times History Published online 5 December 2013 Published in print December 2013 Information© Future Science LtdKeywordscytoplasmic targetdrug deliveryendocytosis heparan sulfate proteoglycannuclear localizationreceptorretrograde transportsyndecan-4Financial & competing interests disclosureB Ughy was supported by the European Union and the State of Hungary, co-financed by the European Social Fund in the framework of TAMOP 4.2.4. A/2–11–11–2012–0001 'National Excellence Program'. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.PDF download