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Nontuberculous Mycobacteria Among Patients Who are Suspected for Multidrug-Resistant Tuberculosis—Need for Earlier Identification of Nontuberculosis Mycobacteria

2009; Elsevier BV; Volume: 337; Issue: 3 Linguagem: Inglês

10.1097/maj.0b013e318185d32f

1538-2990

Payam Tabarsi, Parvaneh Baghaei, Parissa Farnia, Nahal Mansouri, Ehsan Chitsaz, Fatemeh Sheikholeslam, Majid Marjani, Nima Rouhani, Mehdi Mirsaeidi, Narges Alipanah, Majid Amiri, Mohammad Reza Masjedi, Davood Mansouri,

Infectious Diseases and Mycology

Background In this study, we intended to find the prevalence of nontuberculosis mycobacteria (NTM) among patients who are referred as suspected multidrug-resistant tuberculosis (MDR-TB) cases to the only referral center in Iran. Methods All patients referred to our center in 2002–2006 as MDR-TB with histories of treatment with standard and CAT II World Health Organization regimens were included in the study. Sputum smear and culture for acid-fast bacilli were performed for all patients 3 times. Sputum polymerase chain reaction was also performed for all patients. Mycobacterial identification was performed via polymerase chain reaction and routine identification tests for all culture-positive cases. Results Of the 105 patients in the study, 12 (11.43%) were identified to have NTM infection. The identified mycobacteria were classified in order of prevalence as Chelonae (8 cases), Simiae (2 cases), Aloei (1 case), and Farcinogen (1 case). Based on radiologic findings, most of the cases demonstrated bilateral nodularity (83.3%) and also multifocal bronchiectasis (75%). Notably, cavitary lesions were present in 41.7% of the cases. Conclusion Based on the findings of this study, it is essential that such cases be identified before commencing MDR-TB treatment.