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Potentiation of norepinephrine-induced contraction by primary prostaglandin receptor activation in rat aorta

1993; Elsevier BV; Volume: 243; Issue: 2 Linguagem: Inglês

10.1016/0014-2999(93)90382-r

1879-0712

Robert M. Rapoport,

Analytical Methods in Pharmaceuticals

This study investigates the role of primary prostaglandin receptor activation in the modulation of agonist-induced vascular smooth muscle contraction. Prostaglandin F2α induced a concentration-dependent contraction of the rat aorta that was nearly abolished by the thromboxane A2 receptor antagonist, SQ29548. Prostaglandin F2α in the presence of SQ29548 induced leftward shifts of the norepinephrine and KCl concentration-response curves. Nifedipine abolished the leftward shift of the norepinephrine concentration-response curve observed in the presence of prostaglandin F2α and SQ29548. These results suggest that a function of primary prostaglandin receptor activation may be to potentiate agonist-induced contraction. The potentiation is dependent upon the opening of dihydropyridine-sensitive Ca2+ channels.