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BIBTEX RIS

Synergy of a Hepatitis C Virus (HCV) NS4A Antagonist in Combination with HCV Protease and Polymerase Inhibitors

2008; American Society for Microbiology; Volume: 52; Issue: 5 Linguagem: Inglês

10.1128/aac.01208-07

ISSN

1098-6596

Autores

David Wyles, Kelly A. Kaihara, Robert T. Schooley,

Tópico(s)

HIV/AIDS drug development and treatment

Resumo

Rapid emergence of resistance to monotherapy with virus-specific inhibitors necessitates combination therapy. ACH-806 is a hepatitis C virus NS4A inhibitor with a novel mechanism of action and resistance pathway. This compound was synergistic with NS3 protease inhibitors and NS5B nucleoside and nonnucleoside polymerase inhibitors.

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