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Increased renal sodium reabsorption after depletion of the extracellular or intravascular fluid volumes

1966; Elsevier BV; Volume: 6; Issue: 5 Linguagem: Inglês

10.1016/s0022-4804(66)80016-1

1095-8673

Donald S. Gann, Hastings K. Wright,

Hemodynamic Monitoring and Therapy

Renal clearances of inulin, p-aminohippurate, and solute and excretion of sodium and potassium were studied during successive solute diureses in anesthetized dogs before and after no treatment, depletion of extracellular fluid volume by pertioneal dialysis, and depletion of intravascular volume by hemorrhage. External sodium balance and plasma sodium concentration were maintained. Control studies revealed no significant changes in the renal handling of sodium, potassium, or water during the two solute diureses. In contrast, sodium excretion, potassium excretion, and concentrating ability all decreased after contraction of the extracellular or intravascular volumes. The data are consistent with the hypothesis that changes in some function of the intravascular volume lead to enhanced reabsorption of sodium in the proximal tubule. This mechanism may be involved in the retention of sodium by postoperative patients.