Prolonged Sporadic Hemiplegic Migraine Associated With a Novel De Novo Missense ATP1A2 Gene Mutation
2010; Wiley; Volume: 51; Issue: 3 Linguagem: Inglês
10.1111/j.1526-4610.2010.01793.x
ISSN1526-4610
AutoresSara De Sanctis, Gaetano S. Grieco, Laura Breda, Carlo Casali, Manuela Nozzi, Marianna Del Torto, Francesco Chiarelli, Alberto Verrotti,
Tópico(s)Cerebrovascular and genetic disorders
ResumoHemiplegic migraine is a rare form of migraine characterized by periodic attacks of migraine with neurologic aura and transient hemiplegia. There are familial and sporadic cases, both on a genetic basis; we describe the case of a 6‐year‐old boy affected by sporadic hemiplegic migraine, showing a novel ATP1A2 gene missense mutation (p.Gly715Arg) in exon 16. Long‐term treatment with flunarizine resulted in good clinical response and prevention of further attacks.
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