Intravenous administration of replication‐incompetent adenovirus to rhesus monkeys induces thrombocytopenia by increasing in vivo platelet clearance
2003; Wiley; Volume: 123; Issue: 5 Linguagem: Inglês
10.1046/j.1365-2141.2003.04719.x
ISSN1365-2141
AutoresN. Wolins, Jay N. Lozier, T. Eggerman, Estella Jones, Estuardo Aguilar-Córdova, Jaroslav G. Vostal,
Tópico(s)Hematopoietic Stem Cell Transplantation
ResumoA replication-incompetent adenovirus vector was administered to rhesus macaques at 1, 3 and 6 x 1012 particles/kg doses to investigate its toxicity. Platelet count decrements of 28%, 82% and 90%, respectively, were observed, with corresponding platelet half-lives of 69.0, 25.2 and 22.2 h (compared with 111 h in untreated animals). The platelet decline was equivalent for all three doses for 8 h, and platelet count recovery began as early as 8 h after infusion for low-dose recipients, or as late as 24 h for the medium and high dose recipients. These observations suggest that thrombocytopenia is a saturable, reversible consumptive process.
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