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Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells

2009; Elsevier BV; Volume: 386; Issue: 2 Linguagem: Inglês

10.1016/j.bbrc.2009.06.027

1090-2104

Kei Ohnuma, Masahiko Uchiyama, Ryo Hatano, Wataru Takasawa, Yuko Endo, Nam H. Dang, Chikao Morimoto,

Signaling Pathways in Disease

CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.